Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Differential gene expression of Candida albicans under no stress conditions or fluconazole stress

ABSTRACT: Differential gene expression of Candida albicans under no stress conditions or fluconazole stress

PROVIDER: PRJNA764667 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15970856.fastq.gz	Fastqsanger.gz
	SRR15970857.fastq.gz	Fastqsanger.gz
	SRR15970858.fastq.gz	Fastqsanger.gz
	SRR15970859.fastq.gz	Fastqsanger.gz
	SRR15970860.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Differential gene expression of Candida albicans under no stress conditions or fluconazole stress

Project description:QUANT-seq approach was utilized to determine the gene expression in the transcriptome of C. albicans treated with the solvent control DMSO or the antifungal drug fluconazole (FLC). Biological triplicates of C. albicans grown in YPD medium treated with either DMSO or 3 µg/ml fluconazole for 30 minutes at 37˚C were harvested and total RNA was isolated using standard procedures (hot phenol method).

2022-09-20 | GSE184430 | GEO

Copper Availability Influences the Transcriptomic Response of C. albicans to Fluconazole Stress

Project description:We used whole transcriptome profiling (RNA-seq) to analyze the effects of Cu availability on the transcriptomic response of Candida albicans to the azole antifungal drug fluconazole. This study provides a framework for understanding how two treatments work in concert to generate unique impacts on stress response mechanisms of pathogenic fungi.

2021-01-31 | GSE159545 | GEO

Mistranslation accelerates the adaptation of Candida albicans to Fluconazole

Project description:The leucine CUG codon was reassigned to serine in the fungal pathogen Candida albicans. To clarify the biological role of this tuneable codon ambiguity on drug resistance, we evolved C. albicans strains that were engineered to mistranslate the CUG codon at constitutively elevated levels, in the presence and absence of the antifungal drug fluconazole. Elevated levels of mistranslation resulted in the rapid acquisition of resistance to fluconazole.

2016-10-27 | E-SYBR-13 | biostudies-arrayexpress

Comparative genomics of a fluconazole-resistant Candida albicans strain CaLY350.

Project description:To investigate the diversity of gene contents of Candida albicans strain by array-based comparative genomic hybridization (array CGH; aCGH). A fluconazole-resistant Candida albicans strain CaLY350 was selected to carry out the comparative genomics microarray. Two-condition experiment, CaLY350 vs.SN152. Biological replicates: 2 control, 2 transfected, independently grown and harvested. One replicate per array.

2014-06-24 | E-GEOD-48531 | biostudies-arrayexpress

The early transcriptional and post-transcriptional responses to fluconazole in sensitive and resistant Candida albicans (5P-Seq)

Project description:Candida albicans is a leading cause of fungal infections in immunocompromised patients. Management of candidemia relies on a few antifungal agents, with fluconazole being first line therapy. The emergence of fluconazole-resistant strains highlights the pressing need to improve our molecular understanding of the drug response mechanisms. By sequencing the 5’P mRNA degradation intermediates, we show that co-translational mRNA decay is common in C. albicans and characterize how in vivo 5´-3´ exonuclease degradation trails the last translating ribosome. Thus, the study of the 5'P mRNA degradome (5PSeq) offers a simple and affordable way to measure ribosome dynamics and identify codon specific ribosome stalls in response to drugs and amino acid deprivation. Building upon this, we combine RNA-Seq and 5PSeq to study the early response of sensitive and resistant C. albicans isolates to fluconazole. Our results highlight that transcriptional responses, rather than changes in ribosome dynamics, are the main driver of Candida resistance to fluconazole.

2024-10-06 | GSE267940 | GEO

The early transcriptional and post-transcriptional responses to fluconazole in sensitive and resistant Candida albicans (RNA-Seq)

2024-10-06 | GSE267941 | GEO

Comparative genomics of a fluconazole-resistant variant Candida albicans strain CaLY188.

Project description:To investigate the diversity of gene contents of Candida albicans strain by array-based comparative genomic hybridization (array CGH; aCGH). A fluconazole-resistant variant Candida albicans strain CaLY188 was selected to carry out the comparative genomics microarray. Two-condition experiment, CaLY188 vs.SN152. Biological replicates: 2 control, 2 transfected, independently grown and harvested. One replicate per array.

2014-06-24 | E-GEOD-48529 | biostudies-arrayexpress

Transcriptome analysis of Candida albicans exposed to sub-inhibitory amount of fluconazole

Project description:Candida albicans lab strain SC5314 was exposed to 0.5ug/ml fluconazole for 3h. Transcriptome was compared to no drug control.

2022-07-08 | E-MTAB-11881 | biostudies-arrayexpress

Gene expression in response to fluconazole vs. the combination of fluconazole and osthole

Project description:Transcriptional profiling of Candida albicans comparing fluconazole treated cells with fluconazole and osthole treated cells

2017-04-24 | GSE84936 | GEO

Transcription profiling of Candida dubliniensis and Candida albicans under stress conditions

Project description:While Candida dubliniensis and Candida albicans are very close related species, the later is a far more successful yeast pathogen. Several explanations have been pointed out such as discrepancies in fitness, morphogenesis, adherence, or stress resistance. In this study, we investigate the transcriptional reshuffling of C. albicans and C. dubliniensis under conditions that highlight the difference of stress resistances between these strains.

2008-12-01 | E-MEXP-1650 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data