Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Enterobacterales

ABSTRACT: Whole Genome Sequencing of blaNDM Carbapenemase-producing Enterobacterales (CPE) isolates

PROVIDER: PRJNA765801 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR16078900_1.fastq.gz	Fastqsanger.gz
	SRR16078900_2.fastq.gz	Fastqsanger.gz
	SRR16079000_1.fastq.gz	Fastqsanger.gz
	SRR16079000_2.fastq.gz	Fastqsanger.gz
	SRR16079100_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 1028

Similar Datasets

Enterobacterales

Project description:Whole Genome Sequencing of Carbapenemase-producing Enterobacterales (CPE)

| PRJNA757551 | ENA

Clinical Evaluation of Advanced MALDI-TOF MS for Carbapenemase Subtyping in Gram-negative Isolates

Project description:The spread of carbapenemase-producing Enterobacterales (CPE) is emerging as a significant clinical concern in tertiary hospitals and in particular, long-term care facilities with deficiencies in infection control. This study aims to evaluate an advanced matrix-assisted laser desorption/ionization mass spectrometry (A-MALDI) method for the identification of carbapenemases and further discrimination of their subtypes in clinical isolates. The A-MALDI method was employed to detect CPE target proteins. Enhancements were made to improve detectability and mass accuracy through the optimization of MALDI-TOF settings and internal mass calibration. A total of 581 clinical isolates were analyzed, including 469 CPE isolates (388 KPC, 51 NDM, 40 OXA, and 2 GES) and 112 carbapenemase-negative isolates. Clinical evaluation of the A-MALDI demonstrated 100% accuracy and precision in identifying all the collected CPE isolates. Additionally, A-MALDI successfully discriminated individual carbapenemase subtypes (KPC-2 or KPC-3/4; OXA-48 or OXA-181 or OXA-232; GES-5 or GES-24) and also differentiated co-producing carbapenemase strains (KPC & NDM; KPC & OXA; KPC & GES; NDM & OXA), attributed to its high mass accuracy and simultaneous detection capability. A-MALDI is considered a valuable diagnostic tool for accurately identifying CPE and carbapenemase’s subtypes in clinical isolates. It may also aid in selecting appropriate antibiotics for each carbapenemase subtype. Ultimately, we expect that the A-MALDI method will contribute to preventing the spread of antibiotic resistance and improving human public health.

2024-11-26 | PXD058284 | Pride

Enterobacterales

Project description:Long-read Sequencing of Carbapenemase-producing Enterobacterales (CPE) Dataset 2

| PRJNA801416 | ENA

Enterobacterales

Project description:Long-read Sequencing of Carbapenemase-producing Enterobacterales (CPE) Dataset 1

| PRJNA801415 | ENA

Characterization of plasmids mediating carbapenem resistance in Klebsiella pneumoniae in Pretoria, South Africa

Project description:The study aimed to characterize plasmids mediating carbepenem resistance in Klebsiella pneumoniae in Pretoria, South Africa. We analysed 56 K. pneumoniae isolates collected from academic hospital around Pretoria. Based on phenotypic and molecular results of these isolates, 6 representative isolates were chosen for further analysis using long reads sequencing platform. We observed multidrug resistant phenotype in all these isolates, including resistance to aminoglycosides, tetracycline, phenicol, fosfomycin, floroquinolones, and beta-lactams antibiotics. The blaOXA-48/181 and blaNDM-1/7 were manily the plasmid-mediated carbapenemases responsible for carbapenem resistance in the K. pneumoniae isolates in these academic hospitals. These carbapenemase genes were mainly associated with plasmid replicon groups IncF, IncL/M, IncA/C, and IncX3. This study showed plasmid-mediated carbapenemase spread of blaOXA and blaNDM genes mediated by conjugative plasmids in Pretoria hospitals.

2019-10-17 | GSE138949 | GEO

Enterobacterales

Project description:Whole genome sequencing of carbapenemase-producing Enterobacterales from patients and hospital sewage

| PRJNA701733 | ENA

Enterobacterales

Project description:Genomic surveillance of carbapenemase-producing Enterobacterales

| PRJDB16280 | ENA

Enterobacterales

Project description:Whole-genome sequencing of carbapenemase-producing enterobacterales in Toho University Omori Medical Center, Tokyo, Japan

| PRJDB12305 | ENA

Project description:Hybrid assemblies of Carbapenemase-producing Enterobacterales (CPE)

| PRJNA1171009 | ENA

Enterobacterales

Project description:Molecular characterization of carbapenemase-producing Enterobacterales from Czech hospitals

| PRJNA980112 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data