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Changes of gene expression patterns of mouse lung CD45- cells in response to IL-15/IL-15Ra complex whether or not they have MCMV-memory CD8 T cells

ABSTRACT: Changes of gene expression patterns of mouse lung CD45- cells in response to IL-15/IL-15Ra complex whether or not they have MCMV-memory CD8 T cells

PROVIDER: PRJNA768389 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16187317_1.fastq.gz	Fastqsanger.gz
	SRR16187317_2.fastq.gz	Fastqsanger.gz
	SRR16187318_1.fastq.gz	Fastqsanger.gz
	SRR16187318_2.fastq.gz	Fastqsanger.gz
	SRR16187319_1.fastq.gz	Fastqsanger.gz

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Changes of gene expression patterns of mouse lung CD45- cells in response to IL-15/IL-15Ra complex whether or not they have MCMV-memory CD8 T cells

Project description:We report the differences of gene expression pattern of 4 different groups of mouse lung CD45- cells (Naive mouse without IL-15/IL-15Ra complex, Naive mouse with IL-15/IL-15Ra complex, MCMV-infected mouse without IL-15/IL-15Ra complex, and MCMV-infected mouse with IL-15/IL-15Ra complex). We found that mouse with MCMV-memory CD8 T cells response to IL-15/IL-15Ra complex and the behaviors of cancer were changed compared to other groups.

2021-10-06 | GSE185243 | GEO

Changes of gene expression patterns of mouse lung epithelial cells in response to IL-15 whether or not they have MCMV-memory CD8 T cells [mouse in vivo]

Project description:We report the differences of gene expression pattern of 4 different groups of mouse lung epithelial cells (Naive mouse without IL-15, Naive mouse with IL-15, MCMV-infected mouse without IL-15, and MCMV-infected mouse with IL-15). We found that mouse with MCMV-memory CD8 T cells response to IL-15 and the behaviors of cancer were changed compared to other groups.

2020-08-22 | GSE156605 | GEO

Single cell study on PBMCs from Rhesus macaques treated with IL-15/IL-15Ra

Project description:Single cell study on PBMCs from Rhesus macaques treated with IL-15/IL-15Ra

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Bulk RNA sequencing study cynomonolgus macaques treated with escalating doses of IL-15/IL-15Ra

Project description:Bulk RNA sequencing study cynomonolgus macaques treated with escalating doses of IL-15/IL-15Ra

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CD45+ vs CD45- RCC proteome characterization

Project description:Exploration of proteome differences between CD45+ and CD45- cell types in renal cell carcinoma tumors and normal adjacent tissue patient samples.

2020-10-14 | PXD014370 | Pride

Single cell study on PBMCs collected from Rhesus macaques treated with IL-15/IL-15Ra ex-vivo

Project description:Single cell study on PBMCs collected from Rhesus macaques treated with IL-15/IL-15Ra ex-vivo

| PRJNA1237223 | ENA

Bulk RNA sequencing study on PBMCs collected from rhesus macaques treated with IL-15/IL-15Ra ex-vivo

Project description:Bulk RNA sequencing study on PBMCs collected from rhesus macaques treated with IL-15/IL-15Ra ex-vivo

| PRJNA1237082 | ENA

Bulk RNA sequencing study on PBMCs collected from cynomolgus macaques treated with IL-15/IL-15Ra ex-vivo

Project description:Bulk RNA sequencing study on PBMCs collected from cynomolgus macaques treated with IL-15/IL-15Ra ex-vivo

| PRJNA1235794 | ENA

MCMV-experienced ILC1 acquire an m12-dependent memory response

Project description:Innate and adaptive immune cells can acquire “memory” of encounters with a diverse range of activating signals to tune their response to secondary stimuli. Group 1 innate lymphoid cells (ILC1) are recently discovered tissue-resident sentinels that are essential for early host protection from intracellular pathogens at initial sites of infection. However, whether ILC1 function as short-lived effectors or persist and refine their responsiveness following pathogen challenge is not well understood. Furthermore, whether pathogen-derived antigens directly modulate tissue-resident ILC responses remains unclear. Here, we found that liver-resident ILC1 expand locally and persist following the resolution of mouse cytomegalovirus (MCMV) infection. MCMVexperienced ILC1 acquired stable transcriptional, epigenetic, and phenotypic changes, with an enhanced protective effector response to secondary MCMV challenge. Protective memory ILC1 responses were dependent on the MCMV-encoded glycoprotein m12, but not formed during bystander cytokine activation following heterologous infection. Thus, liver ILC1 acquire adaptive features in a MCMV-specific manner.

2019-05-02 | GSE128906 | GEO

Expression of IL-15RA or an IL-15/IL-15RA fusion on CD8+ T cells modifies adoptively transferred T-cell function in cis.

Project description:IL-15 and IL-15 receptor alpha (IL-15RA) play a significant role in multiple aspects of T-cell biology. However, given the evidence that IL-15RA can present IL-15 in trans, the functional capacity of IL-15RA expressed on CD8(+) T cells to modify IL-15 functions in cis is currently unclear. In the current study, we explore the functional consequences of IL-15RA, expression on T cells using a novel method to transfect naive CD8(+) T cells. We observed that RNA nucleofection led to highly efficient, non-toxic, and rapid manipulation of protein expression levels in unstimulated CD8(+) T cells. We found that transfection of unstimulated CD8(+) T cells with IL-15RA RNA led to enhanced viability of CD8(+) T cells in response to IL-15. Transfection with IL-15RA enhanced IL-15-mediated phosphorylation of STAT5 and also promoted IL-15-mediated proliferation in vivo of adoptively transferred naïve CD8(+) T cells. We demonstrated that IL-15RA can present IL-15 via cis-presentation on CD8(+) T cells. Finally, we showed that transfection with a chimeric construct linking IL-15 to IL-15RA cell autonomously enhances the viability and proliferation of primary CD8(+) T cells and cytotoxic potential of antigen-specific CD8(+) T cells. The clinical implications of the current study are discussed.

| S-EPMC3004157 | biostudies-literature

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