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Gastric adenocarcinoma of fundic gland type vs matched normal mucosa

ABSTRACT: Gastric adenocarcinoma of fundic gland type vs matched normal mucosa

PROVIDER: PRJNA771083 | ENA |

REPOSITORIES: ENA

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Gastric adenocarcinoma of fundic gland type vs matched normal mucosa

Project description:Background: Gastric adenocarcinoma of fundic gland type (GA-FG) is rare, and the mechanisms of carcinogenesis and growth progression have not to be elucidated. Results: Transcriptional profiles of 3 fresh-frozen GA-FG and surrounding normal mucosa were compared. Key features of gene expression analysis suggested that TTF-1/NKX2-1 acts as an important transcription factor in GA-FG. This study will provide insight into the mechanism of development. All samples were obtained prior to resection of target lesions in order to minimize effects of cauterization.

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Gene expression changes in patient-matched gastric normal mucosa, adenomas, and carcinomas

Project description:sequential changes in gene expression profiles in the gastric adenoma-carcinoma sequence by analyzing eight patient-matched gastric normal mucosa, adenomas and carcinomas. We examined gene expression changes during the gastric adenoma-carcinoma sequence in 26 snap-frozen samples (normal mucosa, adenoma, and carcinoma samples from eight patients and two additional carcinomas) by oligonucleotide microarray

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microRNA expression profiling among WTX low human gastric cancer tissues and matched adjacent WTX high normal gastric mucosa

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Project description:Gastric Carcinoma is a very serious condition. Tumors are often not detected until late, and 5-year survival rates are 20%. Early diagnosis or prediction of gastric cancer is of outmost importance. Molecularly, those tumours are not well characterized. <br><br> Aim: by use of cDNA microarray to do a three-way comparison of gene expression patterns between tumour (T), flat (non-cancerous) mucosa (N) from stomachs with carcinoma, and normal mucosa in matched controls (K). Our first goal was to look at genes commonly differentially expressed between TvsN and TvsK (both criteria fulfilled) and NvsK. <br><br> Subjects and methods: We analyzed gene expression in tumor and flat mucosa biopsies from seven patients with gastric carcinoma and in age/sex matched samples from healthy individuals. Total RNA was extracted and samples (2 ug total RNA) were labeled for cDNA microarray analysis using Genisphere's 3DNA dendrimer kit. The gene expression patterns for 12759 genes were analyzed.

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Project description:Gastric cancer is one of the most common malignant tumors. Asia has a high incidence of gastric cancer globally. South Korea, Mongolia, Japan and China are the four countries with the highest incidence of gastric cancer in the world. Gansu province in China has the estimated age-standardized incidence rates and mortality rates by Chinese standard population of 62.34/100,000 and 36.94/100,000, respectively, in 2012, which are much higher than the average level of China (22.06/100,000 and 15.16/100,000) in the same year. As a high incidence area of gastric cancer in China, Wuwei city in Gansu province has the prevalence of gastric cancer almost 5 times higher than the average level nationwide. In this study, the cancer tissues and matched adjacent normal mucosa tissues of 5 patients with early gastric cancers who were treated with ESD in Gansu Wuwei Tumor Hospital and the First Hospital of Lanzhou University were collected. All of the patients are from Gansu, China. MicroRNA array was used to find the differences in microRNAs expression profile between the early gastric cancer tissues and the para-cancer normal tissues. It is expected to explore the reasons of the abnormal high incidence of gastric cancer in Gansu Province, China, from the aspect of microRNAs expression profile characteristics.

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