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RNA sequencing of total RNA from spinal cord total lysates of the PS19 tauopathy mouse model.

ABSTRACT: RNA sequencing of total RNA from spinal cord total lysates of the PS19 tauopathy mouse model.

PROVIDER: PRJNA773047 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16501662_1.fastq.gz	Fastqsanger.gz
	SRR16501662_2.fastq.gz	Fastqsanger.gz
	SRR16501663_1.fastq.gz	Fastqsanger.gz
	SRR16501663_2.fastq.gz	Fastqsanger.gz
	SRR16501664_1.fastq.gz	Fastqsanger.gz

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RNA sequencing of total RNA from spinal cord total lysates of the PS19 tauopathy mouse model.

Project description:RNA seqeuncing was perfomed to compare transcriptomic profiles of PS19 and control mice at four and nine months.

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p16-expressing microglia and endothelial cells promote tauopathy and neurovascular abnormalities in PS19 mice

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Project description:Inhibition of soluble epoxide hydrolase (sEH) has been shown to suppress neuroinflammation through stabilizing epoxy fatty acids. Here we examined the role of sEH inhibitor TPPU in PS19 tauopathy mouse model by treating the 6-month-old wild-type and PS19 mice with vehicle or TPPU via drinking water continuously for 12 weeks, followed by performing single nucleus RNA-sequencing of the hippocampal tissues of the treated mice.

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Seed-competent tau monomer initiates pathology in PS19 tauopathy mice

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TFEB-vacuolar ATPase signaling regulates lysosomal activity and immune response in tauopathy

Project description:Transcription factor EB (TFEB) mediates gene expression through binding to the Coordinated Lysosome Expression And Regulation (CLEAR) sequence. We created a knock-in mouse line in which the CLEAR sequence of ATP6V1H was mutated. Crossing the CLEAR mutant with PS19 mice led to higher tau pathology but dampened glial cell activation. snRNA-seq revealed that the CLEAR mutant failed to be activated in tauopathy conditions.

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