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Cellular Architecture of Human Brain Metastases

ABSTRACT: Cellular Architecture of Human Brain Metastases

PROVIDER: PRJNA773428 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16523131.fastq.gz	Fastqsanger.gz
	SRR16523132.fastq.gz	Fastqsanger.gz
	SRR16523133.fastq.gz	Fastqsanger.gz
	SRR16523134.fastq.gz	Fastqsanger.gz
	SRR16523135.fastq.gz	Fastqsanger.gz

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Cellular Architecture of Human Brain Metastases

Project description:Here we present an integrative analysis of 15 human parenchymal BrMs as a resource, generated by single-cell transcriptomics, and complemented with two mouse models- and in silico- approaches. We interrogated the composition of BrM niches, molecularly defined the blood-tumor interface, and reveal stromal immunosuppressive states, enriched with infiltrated T cells and macrophages. Specific single-cell interrogation of metastatic tumor cells provides a novel framework of 8 functional cell programs that coexist or anticorrelate. Collectively, these programs delineate two functional BrM archetypes, one proliferative and the other inflammatory, that are evidently shaped through tumor-immune interactions. Our resource provides a foundation to understand the molecular basis of BrM in patients with tumor cell-intrinsic and host environmental- traits.

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