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Time dependence of volume overload on left ventricular remodeling during preadolescence

ABSTRACT: Time dependence of volume overload on left ventricular remodeling during preadolescence

PROVIDER: PRJNA777042 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16693035_1.fastq.gz	Fastqsanger.gz
	SRR16693035_2.fastq.gz	Fastqsanger.gz
	SRR16693036_1.fastq.gz	Fastqsanger.gz
	SRR16693036_2.fastq.gz	Fastqsanger.gz
	SRR16693037_1.fastq.gz	Fastqsanger.gz

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Project description:We reported the RNAseq analyses of right ventricle (RV) and left ventricle (LV) in neonatal volume overload (VO) and sham-operated SD rat. VO was induced by the fistula between abdominal aorta and inferior vena cava (AVF) within 24 hours postnatally (P1). RNAseq analyses of RV and LV free wall of P7 from VO and sham-operated rat. It demonstrated that the 1806 differentially expressed genes (DEGs) between RV and LV at the neonatal stage were primarily enriched in GTPase mediating signal transduction, insulin signaling pathway and thyroid hormone signaling pathway. VO produced 3 more times DEGs in LV than RV . GO analysis of these DEGs demonstrated that in the top 150 enriched terms, the LV comparison and RV comparison shared 34 terms (22.7%) in common. These commonly enriched terms were primarily associated with GTPase mediating signal transduction. KEGG analysis of these DEGs demonstrated that in the top 30 enriched terms, the LV comparison and RV comparison shared 14 terms (46.7%) in common. And insulin signaling pathway and thyroid hormone signaling pathway are the top two enriched terms in common. Regarding the differently enriched GO terms, they were primarily associated with lipid metabolism and ion channel in RV and primarily associated nucleic acid metabolism in LV. The top two differently enriched KEGG terms were arrhythmogenic right ventricular cardiomyopathy (ARVC) and adipocytokine signaling pathway in RV while microRNAs in cancer and longevity regulating pathway in LV. These results were further confirmed by the determination of metabolites.

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