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Small RNA profiling of differentiated and de-differentiated vascular smooth muscle cell

ABSTRACT: Small RNA profiling of differentiated and de-differentiated vascular smooth muscle cell

PROVIDER: PRJNA777063 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16693148.fastq.gz	Fastqsanger.gz
	SRR16693149.fastq.gz	Fastqsanger.gz
	SRR16693150.fastq.gz	Fastqsanger.gz
	SRR16693151.fastq.gz	Fastqsanger.gz
	SRR16693152.fastq.gz	Fastqsanger.gz

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Small RNA profiling of differentiated and de-differentiated vascular smooth muscle cell

Project description:We report the application of small RNA sequencing for high-throughput profiling of small RNA under 75 bp in vascular smooth muscle cell. By a reading depth of 30M and single stranded sequencing, we generated the small RNA signature on differentiated and de-differentiated vascular smooth muscle cell induced by PDGF-BB and H3K4me2 editing. We found that PDGF-BB and H3K4me2 editing induced de-differentiation modulated miRNA profile significantly, which was demonstrated at least in part responsible for modulated vascular smooth muscle cell phenotype.

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