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The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research

ABSTRACT: The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research

PROVIDER: PRJNA777833 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16770700_1.fastq.gz	Fastqsanger.gz
	SRR16770700_2.fastq.gz	Fastqsanger.gz
	SRR16770701_1.fastq.gz	Fastqsanger.gz
	SRR16770701_2.fastq.gz	Fastqsanger.gz
	SRR16770702_1.fastq.gz	Fastqsanger.gz

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The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research [RRBS]

Project description:Scientific evidence suggests that not only murine scent communication is regulated by major urinary proteins, but that their expression may also vary in response to metabolism via a yet unknown mechanism. Major urinary proteins are expressed mainly in the liver, showing a sexually dimorphic pattern with substantially higher expression in males. Here, we investigate the metabolic implications of a major urinary protein knockout in twelve-week-old male and female C57BL/6N mice during ad libitum feeding. Despite both sexes of major urinary protein knockout mice displayed numerically increased body weight and visceral adipose tissue proportions compared to sex-matched wildtype mice, the main genotype-specific metabolic differences were observed exclusively in males. Male major urinary protein knockout mice exhibited plasma and hepatic lipid accumulation accompanied by a hepatic transcriptome indicating an activation of lipogenesis. These findings match the higher major urinary protein expression in male compared to female wildtype mice, suggesting a more distinct reduction in energy requirements in male compared to female major urinary protein knockout mice. The observed sex-specific anabolic phenotype confirms a role of major urinary protein in metabolism and, since major urinary proteins are not expressed in humans, suggests the major urinary protein knockout mouse as a potential alternative model for translational metabolism research which needs to be further elucidated.

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The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research [RNAseq]

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The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research [RRBS]

Project description:The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research [RRBS]

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The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research [RNAseq]

Project description:The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research [RNAseq]

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The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-08-01 | GSE188158 | GEO

The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research.

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Molecular complexity of the major urinary protein system of the Norway rat, Rattus norvegicus C4PR_LIV

Project description:Major urinary proteins (MUP) are the major component of the urinary protein fraction in house mice (Mus spp.) and rats (Rattus spp.). The structure, polymorphism and functions of these lipocalins have been well described in the western European house mouse (Mus musculus domesticus), clarifying their role in semiochemical communication. The complexity of these roles in the mouse raises the question of similar functions in other rodents, including the Norway rat, Rattus norvegicus. Norway rats express MUPs in urine but information about specific MUP isoform sequences and functions is limited. In this study, we present a detailed molecular characterization of the MUP proteoforms expressed in the urine of two laboratory strains, Wistar Han and Brown Norway, and wild caught animals, using a combination of manual gene annotation, intact protein mass spectrometry and bottom-up mass spectrometry-based proteomic approaches. Detailed sequencing of the urinary MUP isoforms reveals a less complex pattern of primary sequence polymorphism in the rat than the mouse. However, rat MUPs exhibit added complexity in the form of post-translational modifications, including the phosphorylation of Ser4 in some isoforms, and exoproteolytic trimming of specific isoforms.

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