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MicroRNA profile of extracellular vesicles derived from control vehicle- and LIPUS-induced stem cells from the apical papilla

ABSTRACT: microRNA profile of extracellular vesicles derived from control vehicle- and LIPUS-induced stem cells from the apical papilla

PROVIDER: PRJNA778409 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16832573.fastq.gz	Fastqsanger.gz
	SRR16832574.fastq.gz	Fastqsanger.gz
	SRR16832575.fastq.gz	Fastqsanger.gz
	SRR16832576.fastq.gz	Fastqsanger.gz
	SRR16832577.fastq.gz	Fastqsanger.gz

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microRNA profile of extracellular vesicles derived from control vehicle- and LIPUS-induced stem cells from the apical papilla

Project description:Low intensity pulsed ultrasound (LIPUS) is shown to promote osteogenic differentiation and antiinflammation of periodontal mesenchymal stromal cells. We found extracellular vesicles (EVs) derived from LIPUS-induced stem cells from apical papilla (SCAPs) also have stronger anti-inflammatory and osteogenic effects in vitro and in vivo. To obtain clues on whether microRNA (miR) of EVs contribute to stronger anti-inflammatory and osteogenic effects, we analyzed miR expression in EVs from control- and LIPUS-induced SCAPs by deep sequencing. RNA-sequencing suggests that the LIPUS-EVs induce stronger osteogenic differentiation and antiinflammation by using their cargos, including upregulated osteogenic miRNAs to activate the PI3K/Akt and MAPK signaling pathways, and upregulated anti-inflammatory miRNAs to inhibit the TNF-α signaling pathways.

2022-07-02 | GSE188347 | GEO

Comparative bulk RNAseq analysis of Control and Ctnnb1-deficient CXCL12+ apical papilla cells.

Project description:Lack of Ctnnb1 in CXCL12+ apical papilla cells causes a cell fate shift and fail to differentiate into root forming cells such as odontoblasts or cementoblasts. Here, we set out to reveal the transcriptome change induced by Ctnnb1 deficiency in CXCL12+ apical papilla cells

2025-05-21 | GSE248398 | GEO

The human dental apical papilla promotes spinal cord repair through a paracrine mechanism

Project description:Traumatic spinal cord injury is an overwhelming condition that strongly and suddenly impacts the patient’s life and her/his entourage. There are currently no predictable treatments to repair the spinal cord, while many strategies are proposed and evaluated by researchers throughout the world. One of the most promising avenues is the transplantation of stem cells, although its therapeutic efficiency is limited by several factors, among which cell survival at the lesion site. In our previous study, we showed that the implantation of a human dental apical papilla, residence of stem cells of the apical papilla (SCAP), supported functional recovery in a rat model of spinal cord hemisection.

2021-12-20 | GSE191140 | GEO

Expression data of microRNA from human stem cells from apical papilla

Project description:Osteo/odontogenic differentiation is a key process of human stem cells from apical papilla (SCAP) in tooth root development. Emerging evidence indicates microRNAs (miRNAs) play diverse roles in osteogenesis. However, their functions in osteo/odontogenic differentiation of SCAP remain to be elucidated. We used miRNA microarray to analysis differentially expressed miRNAs in order to investigate the role of miRNAs in SCAP osteo/odontogenic differentiation and underlying mechanism.

2021-01-01 | GSE154466 | GEO

High-throughput sequencing of extracellular vesicles from human dermal papilla cells

Project description:The use of dermal papilla cells for hair follicle (HF) regeneration is long accepted much attention. However, cultured dermal papilla cells tend to lose the hair-inducible capability during passaging, which restricts its application. Increasing evidences indicate that dermal papilla cells exert their regulatory function of HF growth mainly through their unique paracrine properties, opening up a way to exosome therapies.This study aimed to explore the effects of exosomes from high and low-passaged human scalp follicle dermal papilla cells (DP-Exos) on hair follicle stem cells (HFSCs) activation and hair growth, and to investigate the underline mechanism. DP-Exos were isolated by ultracentrifugation and cultured with human scalp follicles and HFSCs. The hair elongation and cell proliferation was assessed. Quantitative real-time PCR (qRT-PCR) and Western-blot were performed to detect the expression levels of a class of miRNAs and proteins which have positive roles in regulating hair growth and HFSCs proliferation. High throughput miRNA sequencing of miRNAs in high (P8) and low-passaged (P3) DP-Exos was performed, and the utmost miRNA and its target gene was identified via bioinformatics analysis.

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High-throughput sequencing of extracellular vesicles from human dermal papilla cells

Project description:High-throughput sequencing of extracellular vesicles from human dermal papilla cells

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Impact of a pro-inflammatory stimulus on the miRNA composition of extracellular vesicles (EV) from stem cells from apical papilla (SCAP)

Project description:Impact of a pro-inflammatory stimulus on the miRNA composition of extracellular vesicles (EV) from stem cells from apical papilla (SCAP)

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Simvastatin modulates osteogenic differentiation in stem cells isolated from apical papilla

Project description:Simvastatin modulates osteogenic differentiation in stem cells isolated from apical papilla

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Expression data of microRNA from human stem cells from apical papilla

Project description:Expression data of microRNA from human stem cells from apical papilla

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Transcriptional Profliing of small molecules induced endothelial cells of stem cells from apical papilla (SCAP-ECs), stem cells from apical papilla (SCAP) and human vein endothelial cells (HUVECs)

Project description:Recently, a new strategy has been developed to directly reprogram one cell type towards targeted cell type by using different combinations of small molecule compounds. Here we attempted to induce stem cells from apical papilla (SCAP) into endothelial cells (ECs) by the same strategy. We developed a set of small molecules and growth factors that facilitates the conversion of SCAP into stable endothelial lineage. The SCAP-derived endothelial cells (SCAP-ECs) expressed some up-regulated endothelial specific genes and proteins, exhibited the ability to form functional tubular-like structures in vitro, and contributed to generate blood vessels in vivo. The aim of this study is to compare the ECs-related gene profile of SCAP, SCAP-derived ECs and HUVECs (primary ECs) and to explore whether SCAP-derived ECs showed enriched ECs gene expression.

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