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Bulk RNA of IL-4 and squalene treated MDM

ABSTRACT: Bulk RNA of IL-4 and squalene treated MDM

PROVIDER: PRJNA778539 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16844049_1.fastq.gz	Fastqsanger.gz
	SRR16844049_2.fastq.gz	Fastqsanger.gz
	SRR16844050_1.fastq.gz	Fastqsanger.gz
	SRR16844050_2.fastq.gz	Fastqsanger.gz
	SRR16844051_1.fastq.gz	Fastqsanger.gz

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Bulk RNA of IL-4 and squalene treated MDM

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Project description:Background and Purpose: Squalene is the main hydrocarbon present in extra virgin olive oil and it has been reported to have anti-steatotic properties in different animal models. The aims of this study were to investigate its effects on liver transcriptomics in Male C57BL/6J Apoe-deficient mice. Experimental Approaches: Male C57BL/6J Apoe-deficient mice were fed a purified Western diet with or without squalene during 11 weeks and hepatic squalene content was assessed. Hepatic transcriptomic changes were studied and confirmed by RT-qPCR. Key Results: Squalene supplementation increased its hepatic content. The Cyp2b10 and Cyp2c55 gene expressions were significantly up-regulated by the squalene intake in all animal models, with independence of sex, sexual hormones, dietary fat content, genetic background and dose, and were strongly associated with antioxidant defense capacity and with lipid content and composition. Conclusions and Implications: hepatic squalene exerts its activity through overexpression of these cytochromes and their changes in virgin olive oil diets may be due to squalene.

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