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PPIB-regulated alternative splicing of cell cycle gene contributes to its regulation of cell proliferation

ABSTRACT: PPIB-regulated alternative splicing of cell cycle gene contributes to its regulation of cell proliferation

PROVIDER: PRJNA778646 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16848314_1.fastq.gz	Fastqsanger.gz
	SRR16848314_2.fastq.gz	Fastqsanger.gz
	SRR16848315_1.fastq.gz	Fastqsanger.gz
	SRR16848315_2.fastq.gz	Fastqsanger.gz
	SRR16848316_1.fastq.gz	Fastqsanger.gz

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PPIB-regulated alternative splicing of cell cycle genes contributes to the regulation of cell proliferation.

Project description:BackgroundPeptidylprolyl cis-trans isomerase B (PPIB) plays an important role in the process of inflammation through binding RNA, but the molecular pathogenesis is not yet clearly understood. The objective of this study was to investigate and verify the PPIB-regulated gene expressions and alternative splicing in Hela cells.MethodsWe examined the PPIB-regulated transcriptomes in HeLa cells using RNA-seq data. Differentially expressed genes, alternative splicing analysis were carried out. Functional enrichment analysis was used to define the enrichment of each term.ResultsWe found that PPIB knockdown successfully downregulated PPIB in Hela cells, which promoted cell proliferation (P < 0.001), but no significant effect on cell apoptosis. Ten alternative splicing genes regulated by PPIB were detected in Hela cells. The ten top Gene Ontology biological process analysis and functional pathways of the alternative splicing genes were screened and identified. The pathways where differentially expressed genes are most enriched were toll-like receptor 4 signaling pathways and other signaling pathways relating to inflammation and immune response. In addition, PPIB affects the alternative splicing of multiple genes, and the Gene Ontology-biological process analysis showed that genes significantly related to alternative splicing changes were mainly enriched in the cell cycle (P < 0.05).ConclusionPPIB regulates the alternative splicing of cell cycle-related genes to affect cell proliferation and regulate the occurrence and development of chronic inflammatory diseases such as Nasal polyps.

| S-EPMC9556483 | biostudies-literature

PPIB-regulated alternative splicing of cell cycle gene contributes to its regulation of cell proliferation

Project description:Background: Peptidylprolyl cis-trans isomerase B (PPIB) plays an important function in the process of inflammation through binding RNA, but the clear molecular pathogenesis is not completely understood. The objective of this study was to investigate the PPIB-regulated gene expression and alternative splicing.

2022-10-28 | GSE188372 | GEO

Alternative splicing regulation of cell cycle genes by SPF45/SR140/CHERP complex controls cancer cell proliferation

Project description:Alternative splicing regulation of cell cycle genes by SPF45/SR140/CHERP complex controls cancer cell proliferation

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HDAC9-mediated Epithelial Cell Cycle Arrest in G2/M Contributes to Kidney Fibrosis

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SF3B1-K700E Drives Oncogenic Alternative Splicing of Cell Cycle Checkpoint Genes in Cancer

Project description:SF3B1-K700E Drives Oncogenic Alternative Splicing of Cell Cycle Checkpoint Genes in Cancer

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An extensive program of periodic alternative splicing linked to cell cycle progression

Project description:Progression through the mitotic cell cycle requires periodic regulation of gene function at the levels of transcription, translation, protein-protein interactions, post-translational modification and degradation. However, the role of alternative splicing (AS) in the temporal control of cell cycle is not well understood. By sequencing the human transcriptome through two continuous cell cycles, we identify ~1,300 genes with cell cycle-dependent AS changes. These genes are significantly enriched in functions linked to cell cycle control, yet they do not significantly overlap genes subject to periodic changes in steady-state transcript levels. Many of the periodically spliced genes are controlled by the SR protein kinase CLK1, whose level undergoes cell cycle-dependent fluctuations via an auto-inhibitory circuit. Disruption of CLK1 causes pleiotropic cell cycle defects and loss of proliferation, whereas CLK1 over-expression is associated with various cancers. These results thus reveal a large program of CLK1-regulated periodic AS intimately associated with cell cycle control.

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Transformer 2β regulates alternative splicing of cell cycle regulator genes to promote ovarian cancer cell progression

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MEX3A Promotes Nasopharyngeal Carcinoma Progression by Regulating Alternative Splicing of Cell Cycle-Related Genes

Project description:MEX3A Promotes Nasopharyngeal Carcinoma Progression by Regulating Alternative Splicing of Cell Cycle-Related Genes

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Sibling Cell size contributes to cell cycle progression and cell fate decisions in asymmetrically dividing Drosophila neural stem cells

Project description:Sibling Cell size contributes to cell cycle progression and cell fate decisions in asymmetrically dividing Drosophila neural stem cells

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IGF2BP2-regulated alternative splicing of NFIC causes excessive granulosa cell proliferation in PCOS

Project description:IGF2BP2-regulated alternative splicing of NFIC causes excessive granulosa cell proliferation in PCOS

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