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Kinase activity of nuclear TYRO3 promotes colon cancer malignancy

ABSTRACT: Kinase activity of nuclear TYRO3 promotes colon cancer malignancy

PROVIDER: PRJNA778667 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16853773_1.fastq.gz	Fastqsanger.gz
	SRR16853773_2.fastq.gz	Fastqsanger.gz
	SRR16853774_1.fastq.gz	Fastqsanger.gz
	SRR16853774_2.fastq.gz	Fastqsanger.gz

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Kinase activity of nuclear TYRO3 promotes colon cancer malignancy

Project description:The goal of this study is to compare the different biological functions between nuclear (ICD)-TYRO3- and kinase dead (KD)-TYRO3-overexpressed cells by BRD3 occupancy profiling. We revel that ICD-TYRO3-overexpressed cell were particularly enriched in negatively regulate cell death, regulation of cell cycle, regulation of vascular permeability, positively regulation of EMT, cell-cell adhesion, and regulation of phosphorylation.

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To identify the nuclear partner(s) of TYRO3 in colon cells using LC-Quadrupole Time-of-Flight Mass Spectrometry.

Project description:Colorectal cancer (CRC) is one of the most common death-related cancers worldwide. Aberrant expression of oncogenes is regarded as a predominant factor in CRC development. In our study, we found that TYRO3 intracellular domain nuclear translocation promotes CRC cell proliferation, metastasis, and tumor progression. To identify downstream effector that transmits the cellular functions of nuclear TYRO3, we performed nuclear TYRO3 co-immunoprecipitation.

2023-05-10 | PXD029743 | Pride

Expression data from knockdown of Tyro3 in hepatocellular carcinoma

Project description:Tyro3 is a member of the TAM (Tyro3, Axl and Mer) receptor family. In this study, we want to know potential association between Tyro3 expression in HCC and the involved signaling pathway.

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