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NF-κB encodes history of prior signals to coordinate subsequent cellular responses

ABSTRACT: NF-κB encodes history of prior signals to coordinate subsequent cellular responses

PROVIDER: PRJNA781284 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16970269.fastq.gz	Fastqsanger.gz
	SRR16970270.fastq.gz	Fastqsanger.gz
	SRR16970271.fastq.gz	Fastqsanger.gz
	SRR16970272.fastq.gz	Fastqsanger.gz
	SRR16970273.fastq.gz	Fastqsanger.gz

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NF-κB encodes history of prior signals to coordinate subsequent cellular responses

Project description:We use a novel microfluidic device to provide different concentrations of a point source of TNF-α to a population of NIH3T3 mouse embryonic fibroblasts. These cells are then retrieved in a spatially resolved manner (notated as near, mid, and far from point source) and sequenced using a modified version of the Smart-Seq2 protocol. We find that spatially resolved transcriptomes reveal distinct gene regulation patterns based on TNF dose and/or distance from the point source

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