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Whole ileal tissue from day 6 Dextran Sodium Sulfate (DSS) administered Il17rafl/fl Atoh1-cre+/- mice

ABSTRACT: Whole ileal tissue from day 6 Dextran Sodium Sulfate (DSS) administered Il17rafl/fl Atoh1-cre+/- mice

PROVIDER: PRJNA781993 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16989454_1.fastq.gz	Fastqsanger.gz
	SRR16989454_2.fastq.gz	Fastqsanger.gz
	SRR16989455_1.fastq.gz	Fastqsanger.gz
	SRR16989455_2.fastq.gz	Fastqsanger.gz
	SRR16989456_1.fastq.gz	Fastqsanger.gz

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Whole ileal tissue from day 6 Dextran Sodium Sulfate (DSS) administered Il17rafl/fl;Atoh1-cre+/- mice

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Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis.

Project description:Objective: In this study, we aimed to evaluate the anti-inflammatory properties of nicotine and anatabine in a dextran sulfate sodium (DSS) mouse model of ulcerative colitis (UC). Methods: C57BL/6 male mice (10 groups with 8 animals each) were orally administered nicotine at a concentration of 5 or 20 mg/kg body weight or anatabine at a concentration of 5 or 20 mg/kg body weight for a total of 21 days. Colitis was induced by oral administration of 3.5% DSS in drinking water ad libitum during days 14–21. Colonic samples were collected for transcriptomic analysis and multi-analyte profiling (MAP). Results: Oral administration of anatabine, but not nicotine, reduced the clinical symptoms of DSS-induced colitis. The result of gene expression analysis suggested that anatabine had a restorative effect on global DSS-induced gene expression profiles, while nicotine only had limited effects. Accordingly, MAP findings revealed that anatabine reduced the colonic abundance of DSS-associated cytokines and increased IL‑10 abundance. Conclusions: Our results support the reduction of inflammatory effects by anatabine in the DSS mouse model of UC.

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