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Comparison with gene expression profile of young and aged muscle progenitor cells

ABSTRACT: Comparison with gene expression profile of young and aged muscle progenitor cells

PROVIDER: PRJNA782358 | ENA |

REPOSITORIES: ENA

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Comparison with gene expression profile of young and aged muscle progenitor cells

Project description:Frailty of the locomotory organs has become a widespread problem in the geriatric population. The major factor leading to frailty is an age-associated decrease in muscular mass and a reduced number of muscular cells and myofibers. To understand why decrease self-renew at he gene expression profile the diffeerences between aged and young Muscle progenitor cells(MPSCs). In aged muscular tissues, muscle progenitor cells(MPSCs) are reduced due to abnormalities in their self-renewal and the induction of apoptosis. However, the molecular mechanisms connecting aging-associated physiological changes and the reduction of MPSCs are largely unknown. In this study, we compared the gene expression profile of young and aged MPSCs to identify genes involved in the reduction of MPSCs.

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Project description:Our laboratory wanted to define the transcription profile of aged skeletal muscle. For this reason, we performed a triplicate microarray study on young (3 weeks) and aged (24 months) gatrocnemius muscle from wild-type C57B16 Mice Keywords: other this experiment include 2 samples and 6 replicates

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