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Next generation sequencing analysis in Y-1 mouse adrenocortical cells after dexamethasone treatment

ABSTRACT: Next generation sequencing analysis in Y-1 mouse adrenocortical cells after dexamethasone treatment

PROVIDER: PRJNA782501 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16999824_1.fastq.gz	Fastqsanger.gz
	SRR16999824_2.fastq.gz	Fastqsanger.gz
	SRR16999825_1.fastq.gz	Fastqsanger.gz
	SRR16999825_2.fastq.gz	Fastqsanger.gz
	SRR16999826_1.fastq.gz	Fastqsanger.gz

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Next generation sequencing analysis in Y-1 mouse adrenocortical cells after dexamethasone treatment

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Expression data from H295R_GRα cells following treatment with dexamethasone or RU486

Project description:The human glucocorticoid receptor (GRα) is overexpressed at the molecular and protein level in malignant human adrenocortical cancers. A stable cell line model of GRα overexpression was established using the H295R human adrenocortical cancer cell line. The following results were obtained from gene expression profiling of H295R_GRα and H295R_Control (empty vector) cells following treatment with either a GRα agonist (dexamethasone), GRα antagonist (RU486) or vehicle (ethanol) control.

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Expression data from H295R_GRÎ± cells following treatment with dexamethasone or RU486

Project description:The human glucocorticoid receptor (GRÎ±) is overexpressed at the molecular and protein level in malignant human adrenocortical cancers. A stable cell line model of GRÎ± overexpression was established using the H295R human adrenocortical cancer cell line. The following results were obtained from gene expression profiling of H295R_GRÎ± and H295R_Control (empty vector) cells following treatment with either a GRÎ± agonist (dexamethasone), GRÎ± antagonist (RU486) or vehicle (ethanol) control. H295R_GRÎ± and H295R_Control (empty vector) cells were treated in triplicate for 6 hours with dexamethasone 100 nM, RU486 100 nM or vehicle (ethanol) control.

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