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Identification of TWIST1-associated genomic regions in human breast cancer cell MCF7

ABSTRACT: Identification of TWIST1-associated genomic regions in human breast cancer cell MCF7

PROVIDER: PRJNA784608 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17067370_1.fastq.gz	Fastqsanger.gz
	SRR17067370_2.fastq.gz	Fastqsanger.gz
	SRR17067371_1.fastq.gz	Fastqsanger.gz
	SRR17067371_2.fastq.gz	Fastqsanger.gz
	SRR17067372_1.fastq.gz	Fastqsanger.gz

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Identification of TWIST1-associated genomic regions in human breast cancer cell MCF7

Project description:In this study, we aimed to characterize the stimulatory role of TWIST1 in breast cancer cell proliferation, EMT and metastasis, uncover the underlying molecular mechanism, and identify potential therapeutic targets for treating BLBC. RNA-Seq analysis were performed to identify differentially expressed genes influenced by TWIST1 overexpression in breast cancer cell MCF7. Pathway enrichment analysis and gene set enrichment analysis were performed to identify TWIST1-regulated signaling pathways, particually the cancer-associated pathways. ChIP-Seq analysis was further performed to identify TWIST1-associated genomic regions in MCF7-TWIST1 cells. The potential direct target genes of TWIST1 were identified by combined analysis of the gene expression profiling data and ChIP-Seq data.

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