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RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of pre-mRNAs

ABSTRACT: RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of pre-mRNAs

PROVIDER: PRJNA786639 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17144000.fastq.gz	Fastqsanger.gz
	SRR17144000_1.fastq.gz	Fastqsanger.gz
	SRR17144000_2.fastq.gz	Fastqsanger.gz
	SRR17144600.fastq.gz	Fastqsanger.gz
	SRR17145400_1.fastq.gz	Fastqsanger.gz

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RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of pre-mRNAs III

Project description:Here, we identify RNA-binding motif containing protein 45 (RBM45) as a novel m⁶A reader, enriched in the brain, and highly expressed during embryonic neurodevelopment. We demonstrate that RBM45 recognizes intronic m⁶A and that its primary role is as a direct regulator of pre-mRNA splicing for its target genes, many of which are associated with neurodevelopment. Furthermore, we show that RBM45 is absolutely required for proper differentiation in cultured SH-SY5Y neuroblastoma cells, and that RBM45 regulates splicing of neurodevelopmental target genes central to the activation of gene expression programs that regulate differentiation in vitro.

2022-08-30 | GSE190303 | GEO