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Integrated multilayer omics reveals the genomic, proteomic and metabolic influences of the histidyl dipeptides on heart

ABSTRACT: Integrated multilayer omics reveals the genomic, proteomic and metabolic influences of the histidyl dipeptides on heart

PROVIDER: PRJNA792134 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17327519.fastq.gz	Fastqsanger.gz
	SRR17327520.fastq.gz	Fastqsanger.gz
	SRR17327521.fastq.gz	Fastqsanger.gz
	SRR17327522.fastq.gz	Fastqsanger.gz
	SRR17327523.fastq.gz	Fastqsanger.gz

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Integrated multilayer omics reveals the genomic, proteomic and metabolic influences of the histidyl dipeptides on heart

Project description:This study using a system biology approach of transcriptomics, proteomics and metabolomics, we elucidated the role of endogenous histidyl dipeptides on cellular pathways and myocardial metabolism. Our multi-omics approach for the first-time unravels the landscape of genetic, proteomic, and metabolic changes influenced by histidyl di peptides.

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Integrated Multilayer Omics Reveals the Genomic, Proteomic and Metabolic Influences of the Histidyl Dipeptides on Heart

Project description:Histidyl dipeptides, such as carnosine, present in a micro-millimolar ranges in the heart, are synthesized via the enzyme carnosine synthase (Carns). These dipeptides facilitate glycolysis by proton buffering, form conjugates with reactive aldehydes, such as acrolein, and attenuate ischemia and reperfusion injury. While these dipeptides exhibit multifunctional properties, a composite understanding of their roles in myocardium is lacking. To identify the landscape of histidyl dipeptide mediated responses in the heart, we used a triomics approach of genome wide RNA sequencing, global proteomics and unbiased metabolomics in the cardio specific Carns transgenic (Tg) mice and integrated the three data sets.

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