Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The role of ATAD2 in ovarian cancer growth and progression

ABSTRACT: The role of ATAD2 in ovarian cancer growth and progression

PROVIDER: PRJNA792585 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR17335863.fastq.gz	Fastqsanger.gz
	SRR17335864.fastq.gz	Fastqsanger.gz
	SRR17335865.fastq.gz	Fastqsanger.gz
	SRR17335866.fastq.gz	Fastqsanger.gz
	SRR17335867.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

The role of ATAD2 in ovarian cancer growth and progression

Project description:ATPase Family AAA domain containing 2 (ATAD2) expression is elevated in many cancer types including ovarian cancer. Therefore, we analyzed the role of ATAD2 in ovarian cancer. Pharmacological inhibition of ATAD2 expression in ovarian cancer cell lines resulted in decreased proliferation, and increased cell death.

2024-12-01 | GSE192673 | GEO

The role of DOT1L in ovarian cancer growth and progression

Project description:The role of DOT1L in ovarian cancer growth and progression

| PRJNA663771 | ENA

The role of DOT1L in ovarian cancer growth and progression

Project description:Disruptor of telomeric silencing 1-like (DOT1L) expression is elevated in many cancer types including ovarian cancer. Therefore, we analyzed the role of DOT1L in ovarian cancer. Pharmacological inhibition of DOT1L expression in ovarian cancer cell lines resulted in decreased proliferation, and increased cell death.

2023-09-15 | GSE158019 | GEO

The role of CDC7 in Melanoma cancer growth and progression

Project description:The role of CDC7 in Melanoma cancer growth and progression

| PRJNA665990 | ENA

The role of UBE2T in breast cancer growth and progression

Project description:The role of UBE2T in breast cancer growth and progression

| PRJNA658487 | ENA

Role of FTO in ovarian cancer

Project description:Role of FTO in ovarian cancer

| PRJNA538933 | ENA

The role of ASAH1 in Triple negative breast cancer (TNBC) growth and progression

Project description:The role of ASAH1 in Triple negative breast cancer (TNBC) growth and progression

| PRJNA1040259 | ENA

COL11A1 promotes tumor progression and predicts poor clinical outcome in ovarian cancer.

2014-01-01 | GSE44104 | GEO

MNRR1 is a driver of ovarian cancer progression

Project description:MNRR1 is a driver of ovarian cancer progression

| PRJNA903221 | ENA

COL11A1 promotes tumor progression and predicts poor clinical outcome in ovarian cancer.

Project description:Biomarkers that predict disease progression might assist the development of better therapeutic strategies for aggressive cancers, such as ovarian cancer. Here, we investigated the role of collagen type XI alpha 1 (COL11A1) in cell invasiveness and tumor formation and the prognostic impact of COL11A1 expression in ovarian cancer. Microarray analysis suggested that COL11A1 is a disease progression-associated gene that is linked to ovarian cancer recurrence and poor survival. Whole tumor gene expression profiling was conducted on tissue samples from 60 ovarian cancer patients, and characteristics and clinico-pathological features of the patients are provided. We used several steps to analyze the expression profiles of the samples to identify the genes whose expression values correlate with survival, recurrence and advanced disease stage. First, using hazard ratios from univariate Cox regression analysis, the top 200 survival-related genes were evaluated for intersection with the top 200 recurrence-related genes, and 44 genes were obtained. Second, we examined the 44 genes that met the criteria of fold-change values between advanced stage and early stage samples of greater than 2 or less than 0.5. Ultimately, 17 genes were identified. A heat map of the 17 genes is depicted in the associated publication. Gene ontology and pathway enrichment analyses of the 17 genes were performed using Database for Annotation, Visualization and Integrated Discovery (DAVID). The major cellular component, biological process and molecular function of the 17 genes are associated with the extracellular region, intracellular signaling cascade, and protein binding and bridging, respectively. Two genes, COL11A1 and COL4A6, are involved in ECM-receptor interaction pathways. Notably, COL11A1 displayed the highest fold-change value in ovarian cancer disease progression; therefore, we selected COL11A1 for further experimental analysis.

2014-01-01 | E-GEOD-44104 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data