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Epigenetic changes of Raji Epstein–Barr viral genome in reponse to byrostatin treatment

ABSTRACT: Epigenetic changes of Raji Epstein–Barr viral genome in reponse to byrostatin treatment

PROVIDER: PRJNA793426 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17395335_1.fastq.gz	Fastqsanger.gz
	SRR17395335_2.fastq.gz	Fastqsanger.gz
	SRR17395336_1.fastq.gz	Fastqsanger.gz
	SRR17395336_2.fastq.gz	Fastqsanger.gz
	SRR17395337_1.fastq.gz	Fastqsanger.gz

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Epigenetic changes of Raji Epstein–Barr viral genome in reponse to byrostatin treatment

Project description:We report the application of cut&tag technology for high-throughput profiling of histone modifications Raji Epstein–Barr viral genome in reponse to bryostatin treatment. Dual- and tri-methylation of lysine 4 on histone H3 protein indicate genes that are actively expressed/regulated. Tri-methylation of lysine 27 on histone H3 protein marks genes that are negatively regulated or suppressed for expression.

2022-01-05 | GSE192837 | GEO

Antibodies against the mono-methylated Arginine-Glycine repeat (MMA-RG) of the Epstein-Barr virus nuclear antigen 1 (EBNA1) identify potential cellular proteins targeted in viral transformation

Project description:The viral nuclear antigen 1 (EBNA1) of Epstein Barr (EBV) features two functionally redundant Arginine-Glycine (RG) repeats that contain symmetrically and asymmetrically di-methylated (SDMA/ADMA) and also mono-methylated (MMA) Arginine residues. We generated mouse monoclonal antibodies against the mono-methylated RG-repeat between aa 328-377. In addition to detect MMA-EBNA1, we aimed at the identification of cellular proteins that are bound to MMA-modified EBNA1 in EBV-positive Raji cells.

2025-03-05 | PXD051181 | Pride

The role of viral microRNAs in Burkitt Lymphoma: the Epstein Barr-encoded Bart-6-3p microRNA regulates cell proliferation and immunosurveillance

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Project description:RATIONALE: The Epstein Barr virus can cause cancer and lymphoproliferative disorders. Ganciclovir is an antiviral drug that acts against the Epstein Barr virus. Arginine butyrate may make virus cells more sensitive to ganciclovir. Combining ganciclovir and arginine butyrate may kill more Epstein Barr virus cells and tumor cells. PURPOSE: Phase I trial to study the effectiveness of arginine butyrate plus ganciclovir in treating patients who have cancer or lymphoproliferative disorders that are associated with the Epstein Barr virus.

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Project description:Epstein-Barr virus is a gamma-herpes virus that is causally associated with several lymphomas and carcinomas. This virus encodes at least 25 pre-miRNAs, which are expressed in infected cells to yield more than 50 detected mature miRNAs. miRNAs are small, non-coding RNAs that inhibit gene expression by promoting the inhibition of translation or of degradation of mRNAs. Currently, the function of these viral miRNAs and the contribution they provide to EBV's life-cycle remain largely unknown, due to difficulties in identifying cellular and viral genes regulated by these miRNAs. We have compared and contrasted two methods to identify targets of viral miRNAs in order to identify the advantages and limitations of each method to aid in uncovering the functions of EBV's miRNAs. Examination of RISC (RNA Induced Silencing Complexes) associated transcripts under 2 conditions in BJAB cells

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2022-10-07 | MSV000090486 | MassIVE

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