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The transcriptional regulator Prdm1 is a master gene for the early development of the sensory whisker follicle and is wired to the Lef1 circuitry [CUT&TAG]

ABSTRACT: The transcriptional regulator Prdm1 is a master gene for the early development of the sensory whisker follicle and is wired to the Lef1 circuitry [CUT&TAG]

PROVIDER: PRJNA793445 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17395579_1.fastq.gz	Fastqsanger.gz
	SRR17395579_2.fastq.gz	Fastqsanger.gz
	SRR17395580_1.fastq.gz	Fastqsanger.gz
	SRR17395580_2.fastq.gz	Fastqsanger.gz
	SRR17395581_1.fastq.gz	Fastqsanger.gz

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The transcriptional regulator Prdm1 is a master gene for the early development of the sensory whisker follicle and is wired to the Lef1 circuitry [4C-seq]

Project description:Prdm1 encodes the transcriptional repressor PRDM1/BLIMP1 and Prdm1 mutant mice are one of the rare mutant strains that do not develop whisker hair follicles while still displaying a pelage. We demonstrate that Lef1, a key mediator of the Wnt/Beta Catenin pathway, acts upstream of Prdm1 and identify a primate specific deletion of a Lef1 enhancer, Leaf. This loss may have been significant in the evolutionary process, leading to the progressive defunctionalization and disappearance of vibrissae in primates.

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The transcriptional regulator Prdm1 is a master gene for the early development of the sensory whisker follicle and is wired to the Lef1 circuitry [CUT&TAG]

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The transcriptional regulator Prdm1 is a master gene for the early development of the sensory whisker follicle and is wired to the Lef1 circuitry.

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The transcriptional regulator Prdm1 is a master gene for the early development of the sensory whisker follicle and is wired to the Lef1 circuitry [4C-seq]

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The transcriptional regulator Prdm1 is a master gene for the early development of the sensory whisker follicle and is wired to the Lef1 circuitry.

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