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Super enhancers orchestrate osteogenesis program through navigation and initiation effects of Brd4 on Zbtb16 [RNA-Seq]

ABSTRACT: Super enhancers orchestrate osteogenesis program through navigation and initiation effects of Brd4 on Zbtb16 [RNA-Seq]

PROVIDER: PRJNA793900 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17415451.fastq.gz	Fastqsanger.gz
	SRR17415452.fastq.gz	Fastqsanger.gz
	SRR17415453.fastq.gz	Fastqsanger.gz
	SRR17415454.fastq.gz	Fastqsanger.gz
	SRR17415455.fastq.gz	Fastqsanger.gz

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Super enhancers orchestrate osteogenesis program through navigation and initiation effects of Brd4 on Zbtb16

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Super enhancers orchestrate osteogenesis program through navigation and initiation effects of Brd4 on Zbtb16 [ChIP-Seq]

Project description:Super enhancers orchestrate osteogenesis program through navigation and initiation effects of Brd4 on Zbtb16 [ChIP-Seq]

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Super enhancers orchestrate osteogenesis program through navigation and initiation effects of Brd4 on Zbtb16 [CUT&TAG]

Project description:Super enhancers orchestrate osteogenesis program through navigation and initiation effects of Brd4 on Zbtb16 [CUT&TAG]

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Super enhancers orchestrate osteogenesis program through navigation and initiation effects of Brd4 on Zbtb16 [CUT&TAG]

Project description:We performed multiomic high-throughput sequencing to recapitulated the primary mechanism of mesenchymal stem cells osteogenesis. We analysed the H3K27ac ChIP-seq, BRD4 CUT&Tag and RNA-seq data before and after osteogenesis, and identified super enhancers (SEs) regulated osteogenic identity genes in MSCs.

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Super enhancers orchestrate osteogenesis program through navigation and initiation effects of Brd4 on Zbtb16 [ChIP-Seq]

Project description:We performed multiomic high-throughput sequencing to recapitulated the primary mechanism of mesenchymal stem cells osteogenesis. We analysed the H3K27ac ChIP-seq and RNA-seq data before and after osteogenesis, and identified super enhancers (SEs) regulated osteogenic identity genes in MSCs.

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Super enhancers orchestrate osteogenesis program through navigation and initiation effects of Brd4 on Zbtb16 [RNA-Seq]

Project description:We performed multiomic high-throughput sequencing to recapitulated the primary mechanism of mesenchymal stem cells osteogenesis. We analysed the H3K27ac ChIP-seq and RNA-seq data before and after osteogenesis, and identified super enhancers (SEs) regulated osteogenic identity genes in MSCs.

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Super enhancers orchestrate osteogenesis program through navigation and initiation effects of Brd4 on Zbtb16

Project description:This SuperSeries is composed of the SubSeries listed below.

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Zbtb16 regulates social cognitive behaviors and neocortical development

Project description:Recent genomic studies suggest that a single gene is involved in multiple diseases, however it is unclear what mechanism destined for different diseases by a single gene. Mutations of ZBTB16 are associated with autism spectrum disorder (ASD) and schizophrenia (SCZ), but how ZBTB16 fates ASD or SCZ are unknown. Here we show the deletion of Zbtb16 in mice leads to both ASD- and SCZ-like behaviors such as social impairment, repetitive behaviors, risk-taking behaviors, and cognitive impairment. To elucidate the mechanism underlying the behavioral phenotypes, we carried out histological studies and observed impairments in thinning of neocortical layer 6 (L6) and a reduction of TBR1+ neurons in the prefrontal cortex (PFC) of Zbtb16 KO mice. Furthermore, we found increased dendritic spines and microglia as well as developmental defects in oligodendrocytes and neocortical myelination in the PFC of Zbtb16 KO mice. Using a genomics approach, we identified the Zbtb16-transcriptome that includes genes involved in both ASD and SCZ pathophysiology and neocortical maturation such as neurogenesis and myelination. Co-expression networks further identified Zbtb16-correlated modules that are unique to ASD or SCZ respectively. Our study provides insight into the differential role of the single gene ZBTB16 in ASD and SCZ.

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Osteogenesis RNA-Seq

Project description:Osteogenesis RNA-Seq

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Project description:Osteogenesis Chip-Seq

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