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VGLL1 regulates extraembryonic lineage specification in human [CUT&TAG]

ABSTRACT: VGLL1 regulates extraembryonic lineage specification in human [CUT&TAG]

PROVIDER: PRJNA796962 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR17607104_1.fastq.gz	Fastqsanger.gz
	SRR17607104_2.fastq.gz	Fastqsanger.gz
	SRR17607105_1.fastq.gz	Fastqsanger.gz
	SRR17607105_2.fastq.gz	Fastqsanger.gz
	SRR17607109_1.fastq.gz	Fastqsanger.gz

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VGLL1 regulates extraembryonic lineage specification in human [CUT&TAG]

Project description:Placenta abnormality is one of the key reasons for early pregnancy loss but the regulatory mechanisms underlying placenta formation are largely unknown. Here, we applied a human naïve pluripotent stem cell (PSC) derived TE model to explore the driven regulatory machinery. We demonstrate that VGLL1 (vestigial like family member 1) is crucial for TE self-renewal and TE-specific gene expression, thus suppressing VGLL1 leads to severely impaired cell proliferation and skewed TE induction. VGLL1 exerts its function through interacting with TEAD4 (TEA domain transcription factor 4) and colocalize at target gene promoters and enhancers. Further investigation uncovers the enrichment of H3K27ac active histone marks at genomic regions occupied by VGLL1-TEAD4 complex, indicates a close association between them. Overall, our data reveals the critical function model of VGLL1-TEAD4 in human TE derivation, highlighting a potential interspecies difference between human and mouse TE induction.

2023-12-18 | GSE193618 | GEO

VGLL1 regulates extraembryonic lineage specification in human [RNA-Seq]

Project description:VGLL1 regulates extraembryonic lineage specification in human [RNA-Seq]

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VGLL1 regulates extraembryonic lineage specification in human [ATAC-Seq]

Project description:VGLL1 regulates extraembryonic lineage specification in human [ATAC-Seq]

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VGLL1 regulates extraembryonic lineage specification in human [RNA-seq II]

Project description:VGLL1 regulates extraembryonic lineage specification in human [RNA-seq II]

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VGLL1 regulates extraembryonic lineage specification in human [RNA-Seq]

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VGLL1 regulates extraembryonic lineage specification in human [ATAC-Seq]

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VGLL1 regulates extraembryonic lineage specification in human [RNA-seq II]

Project description:Placenta abnormality is one of the key reasons for early pregnancy loss but the regulatory mechanisms underlying placenta formation are largely unknown. Here, we applied a human naïve pluripotent stem cell (PSC) derived TE model to explore the driven regulatory machinery. We demonstrate that VGLL1 (vestigiallikefamilymember1) is crucial for TE self-renewal and TE-specific gene expression, thus suppressing VGLL1 leads to severely impaired cell proliferation and skewed TE induction. VGLL1 exerts its function through interacting with TEAD4 (TEA domain transcription factor 4) and colocalize at target gene promoters and enhancers. Further investigation uncovers the enrichment of H3K27ac active histone marks at genomic regions occupied by VGLL1-TEAD4 complex, indicates a close association between them. Overall, our data reveals the critical function model of VGLL1-TEAD4 in human TE derivation, highlighting a potential interspecies difference between human and mouse TE induction.

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VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification [scRNA-Seq]

Project description:In contrast to rodents, the mechanisms underlying human trophectoderm and early placenta specification are understudied due to ethical barriers and the scarcity of embryos. Recent reports have shown that human pluripotent stem cells (PSCs) can differentiate into trophectoderm (TE)-like cells (TELCs) and trophoblast stem cells (TSCs), offering a valuable in vitro model to study early placenta specification. Here, we demonstrate that the VGLL1 (vestigial-likefamilymember1), which is highly expressed during human and non-human primate TE specification in vivo but is negligibly expressed in mouse, is a critical regulator of cell fate determination and self-renewal in human TELCs and TSCs derived from naïve PSCs. Mechanistically, VGLL1 partners with the transcription factor TEAD4 (TEA domain transcription factor 4) to regulate chromatin accessibility at target gene loci through histone acetylation and acts in cooperation with GATA3 and TFAP2C. Our work is relevant to understand primate early embryogenesis and how it differs from other mammalian species.

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HCT116_SMARCA4 CUT&Tag

Project description:HCT116_SMARCA4 CUT&Tag

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CUT&TAG of OE19 cell line

Project description:To map the chromatin binding sites for SMC1 in OE19 cells, we performed CUT&TAG.

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