Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA Sequencing Analysis between Control and CGA knockdown Multi-drug resistant Cells

ABSTRACT: RNA Sequencing Analysis between Control and CGA knockdown Multi-drug resistant Cells

PROVIDER: PRJNA797436 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR17622600_1.fastq.gz	Fastqsanger.gz
	SRR17622600_2.fastq.gz	Fastqsanger.gz
	SRR17622601_1.fastq.gz	Fastqsanger.gz
	SRR17622601_2.fastq.gz	Fastqsanger.gz
	SRR17622602_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 36

Similar Datasets

RNA Sequencing Analysis between Control and CGA knockdown Multi-drug resistant Cells

Project description:The aim of this study is to compare the CGA Knockdown multi-drug resistant (MDR) cells (SGC7901/ADR and SGC7901/VCR) to the control cells. The total RNA of the indicated cells were extracted using Qiagen RNA Extraction Kit and RNA sequencing was performed. Significant differences in genes and signaling pathways were found between CGA knockdown and control MDR cells. This study provides a basis for applying RNA sequencing techniques to characterize targets in MDR cells.

2022-03-30 | GSE193739 | GEO

Piscirickettsia salmonis CGA/3731

Project description:Piscirickettsia salmonis CGA/3731 Genome sequencing

| PRJNA232514 | ENA

Towards phage therapy against multi-drug resistant Klebsiella pneumoniae

Project description:Towards phage therapy against multi-drug resistant Klebsiella pneumoniae

| PRJEB56576 | ENA

Chromogranin A (CgA) Deficiency Attenuates Tauopathy by Altering Epinephrine–Alpha-Adrenergic Receptor Signaling

Project description:Our previous studies have indicated that insulin resistance, hyperglycemia, and hypertension in aged wild-type (WT) mice can be reversed in mice lacking chromogranin-A (CgA-KO mice). These health conditions are associated with a higher risk of Alzheimer’s disease (AD). CgA, a neuroendocrine secretory protein has been detected in protein aggregates in the brains of AD patients. Here, we determined the role of CgA in tauopathies, including AD (secondary tauopathy) and corticobasal degeneration (CBD, primary tauopathy). We found elevated levels of CgA in both AD and CBD brains, which were positively correlated with increased phosphorylated tau in the frontal cortex. Furthermore, CgA ablation in a human P301S tau (hTau) transgenic mice (CgA-KO/hTau) exhibited reduced tau aggregation, resistance to tau spreading, and an extended lifespan, coupled with improved cognitive function. Transcriptomic analysis of mice cortices highlighted altered levels of alpha-adrenergic receptors (Adra) in hTau mice compared to WT mice, akin to AD patients. Since CgA regulates the release of the Adra ligands epinephrine (EPI) and norepinephrine (NE), we determined their levels and found elevated EPI levels in the cortices of hTau mice, AD and CBD patients. CgA-KO/hTau mice exhibited reversal of EPI levels in the cortex and the expression of several affected genes, including Adra1 and 2, nearly returning them to WT levels. Treatment of hippocampal slice cultures with EPI or an Adra1 agonist intensified, while an Adra1 antagonist inhibited, tau hyperphosphorylation and aggregation. These findings reveal a critical role of CgA in regulation of tau pathogenesis via the EPI-Adra signaling axis.

2025-04-07 | GSE274459 | GEO

RNA Sequencing Facilitates Quantitative Analysis of shL3MBTL2 ,CGA-OE and corresponding control Transcriptomes

Project description:L3MBTL2 is a crucial component of ncPRC1.6 and has been implicated in transcriptional repression and chromatin compaction. However, the repression mechanism of L3MBTL2 and its biological functions are largely undefined. CGA encodes the alpha subunit of glycoprotein hormones, however, we showed that CGA plays an individual tumor suppressor role in PDAC. The goals of this part study are to compare transcriptome profiling of PANC-1-shL3MBTL2 cells or PANC-1-CGA-OE cells to their corresponding control cells. By identifying differentially expressed genes (DEGs) and enrichment pathways, the mechanism of L3MBTL2 and CGA in pancreatic cancer can be better studied.

2022-01-01 | GSE184834 | GEO

Multi-drug resistant Enterobacteriaceae isolates from raw meats

Project description:Multi-drug resistant ESBL-producing Enterobacteriaceae isolates from retail raw meats in markets of Singapore

| PRJEB34176 | ENA

Comparative genomic hybridization of Salmonella enteric serotype Newport strains from the US and UK to understand the emergence of highly virulent multi-drug resistant strains

Project description:Comparison between the multi-drug resistance Salmonella enteric serotype Newport strains from the US and the pan-susceptible strains from the UK

2009-10-02 | E-MEXP-1846 | biostudies-arrayexpress

SWATH-MS data of Multi Drug Resistant and drug sensitive Escherichia coli isolated from anthropogenic river Yamuna, Delhi, India

Project description:Integrative proteo-trnascriptomics analysis of MDR abd drug sensitive E. coli strains isolated from river Yamuna, Delhi, India to identify novel drug targets against Multi drug Resistant E. coli

2025-02-10 | PXD048998 | Pride

Genomic insights into multi-drug resistant Enterobacter hormaechei strains isolated from seafood at retail

Project description:Multi-drug resistant Enterobacter hormaechei strains from seafood

| PRJEB89346 | ENA

Global mapping of RNA-binding domains in multi-drug resistant Staphylococcus aureus

Project description:Global mapping of RNA-binding domains in multi-drug resistant Staphylococcus aureus

| PRJNA687253 | ENA