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ICLIP of endogenous PURA in neuronal precursor cells

ABSTRACT: iCLIP of endogenous PURA in neuronal precursor cells

PROVIDER: PRJNA798376 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR17653875.fastq.gz	Fastqsanger.gz
	SRR17653876.fastq.gz	Fastqsanger.gz

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iCLIP of endogenous PURA in neuronal precursor cells

Project description:The protein PURA binds to DNA and RNA and has been suggested to be implicated in different cellular functions. Here, we show that PURA predominantly resides in the cytoplasm, where it binds to a large set of transcripts.

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iCLIP of endogenous PURA in HeLa cells

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iCLIP of FLAG-PURA overexpression with anti-PURA12D11 antibody in HeLa cells

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RNAseq of PURA knockdown in HeLa cells

Project description:Here, we show that PURA predominantly resides in the cytoplasm, where it binds to a large set of transcripts. Many of these transcripts change abundance in response to PURA depletion, in parts reflected in altered protein expression levels. A closer inspection of the regulated proteins indicates a role of PURA in immune responses, mitochondrial function, autophagy and processing (P)-body activity.

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