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ABSTRACT: HZRG-MCD

PROVIDER: PRJNA799458 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR17703728.fastq.gz	Fastqsanger.gz
	SRR17703729.fastq.gz	Fastqsanger.gz
	SRR17703730.fastq.gz	Fastqsanger.gz
	SRR17703731.fastq.gz	Fastqsanger.gz
	SRR17703732.fastq.gz	Fastqsanger.gz

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Difference of microRNA expressions between a mouse model of NASH(MCD diet) and normal mouse.

Project description:The microRNAs expression was markedly altered with the MCD diet. Using a custom microarray platform, we analyzed the expression levels of 1135 mouse microRNA probes in liver tissue that were fed MCD diet.

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Project description:Malformations of cortical development (MCD) are present in up to 40% of children with pharmacoresistant epilepsy. Although epilepsy surgery can be successful in a subset of children, not all forms of MCD are operable. Understanding the genetic and neurobiological mechanisms underlying MCD and MCD-related epilepsy are necessary for the development of novel anti-epilepsy drugs. The tish (telencephalic internal structural heterotopia) rat is a unique model of MCD and spontaneous seizures, but the underlying genetic mutation has been, heretofore, unknown. DNA and RNA-sequencing revealed that a deletion encompassing a previously unannotated exon markedly diminished EML1 transcript and protein abundance in the tish brain. Developmental electrographic characterization of the tish rat demonstrated spontaneous spike-wave discharge (SWD) bursts beginning as early as postnatal day (P) 17. A dihybrid cross demonstrated that the mutantEml1 allele segregates with the observed dysplastic cortex and SWD bursts in monogenic autosomal recessive frequencies. Our data link the development of the bilateral, heterotopic dysplastic cortex of the tish rat to a mutation in Eml1 and provide a novel rat model of MCD.

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