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Human papillomavirus 42 is an oncogenic driver in Digital Papillary Adenocarcinoma [transductions]

ABSTRACT: Human papillomavirus 42 is an oncogenic driver in Digital Papillary Adenocarcinoma [transductions]

PROVIDER: PRJNA803908 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17900881.fastq.gz	Fastqsanger.gz
	SRR17900882.fastq.gz	Fastqsanger.gz
	SRR17900883.fastq.gz	Fastqsanger.gz
	SRR17900884.fastq.gz	Fastqsanger.gz
	SRR17900885.fastq.gz	Fastqsanger.gz

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Human papillomavirus 42 is an oncogenic driver in Digital Papillary Adenocarcinoma.

Project description:Human papillomavirus 42 is an oncogenic driver in Digital Papillary Adenocarcinoma.

| PRJNA803904 | ENA

Human papillomavirus 42 is an oncogenic driver in Digital Papillary Adenocarcinoma [full_genomes]

Project description:The skin serves as a barrier to the environment and is constantly exposed to viral pathogens. However, whether and how viral pathogens contribute to oncogenesis of rare skin cancers has not been explored. We analyzed 18 skin cancers by exploiting sparse off-target reads from commonly available next-generation sequencing data and identify human papillomavirus 42 (HPV42) reads in digital papillary adenocarcinoma (DPA). We show that HPV42 recapitulates the molecular hallmarks of oncogenic HPVs and shares a conserved transcriptomic fingerprint of HPV-transformation. Finally, we show that HPV42 relies on established cellular targets of oncogenic HPVs for its transforming activity. The discovery of HPV42 as a novel oncogenic driver highlights the utility of next-generation sequencing data for the discovery of novel pathogen-disease associations and suggests expansion of current HPV vaccination programs to reduce the cancer burden in humans.

2022-10-10 | GSE196216 | GEO

Human papillomavirus 42 is an oncogenic driver in Digital Papillary Adenocarcinoma [tumors]

2022-10-10 | GSE196215 | GEO

Human papillomavirus 42 is an oncogenic driver in Digital Papillary Adenocarcinoma [transductions]

2022-10-10 | GSE196217 | GEO

Human papillomavirus 42 is an oncogenic driver in Digital Papillary Adenocarcinoma [tumors]

Project description:Human papillomavirus 42 is an oncogenic driver in Digital Papillary Adenocarcinoma [tumors]

| PRJNA803909 | ENA

Human papillomavirus 42 is an oncogenic driver in Digital Papillary Adenocarcinoma [full_genomes]

Project description:Human papillomavirus 42 is an oncogenic driver in Digital Papillary Adenocarcinoma [full_genomes]

| PRJNA803907 | ENA

Human papillomavirus 42 is an oncogenic driver in Digital Papillary Adenocarcinoma.

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-10-10 | GSE196218 | GEO

Quantitative TMT-MS of HPV42, HPV16 or empty vector transduced keratinocytes.

Project description:The skin serves as a barrier to the environment and is constantly exposed to viral pathogens. Whether viral pathogens contribute to the oncogenesis of rare skin cancers has not been systematically explored. Here, we analyzed 18 skin cancer types by exploiting off-target reads from commonly available next-generation sequencing data. We identified human papillomavirus 42 (HPV42) in all digital papillary adenocarcinoma (DPA) cases but not in any of 11,091 tumors from common cancer types. HPV42 was previously not described as an oncogenic driver, yet we show that HPV42 recapitulates the molecular hallmarks of oncogenic HPVs. Using a machine learning approach, we identified a conserved transcriptomic fingerprint of HPV transformation common to oncogenic HPVs, including HPV42. Collectively, our results establish HPV42 as an oncogenic HPV, which has implications for the diagnosis and treatment for DPA patients.

2022-10-18 | PXD031764 | Pride

RNA-Sequencing of human papillary thyroid carcinomas

Project description:RNA-Sequencing analysis of 18 papillary thyroid carcinoma biopsies and of 4 healthy donors' thyroids. In this analysis we assessed differential gene expression and investigated the mutational landscape in this tumor type. Analysis of gene fusion was also performed, leading to the identification of a novel chimeric transcript, potential driver in tumor initiation. Total RNA isolated from 18 papillary thyroid carcinoma biopsies and 4 healthy donors' thyroids.

2015-05-01 | E-GEOD-64912 | biostudies-arrayexpress

Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell-like Program Conserved in HPV-Positive Cancers.

Project description:The skin is exposed to viral pathogens, but whether they contribute to the oncogenesis of skin cancers has not been systematically explored. Here we investigated 19 skin tumor types by analyzing off-target reads from commonly available next-generation sequencing data for viral pathogens. We identified human papillomavirus 42 (HPV42) in 96% (n = 45/47) of digital papillary adenocarcinoma (DPA), an aggressive cancer occurring on the fingers and toes. We show that HPV42, so far considered a nononcogenic, "low-risk" HPV, recapitulates the molecular hallmarks of oncogenic, "high-risk" HPVs. Using machine learning, we find that HPV-driven transformation elicits a germ cell-like transcriptional program conserved throughout all HPV-driven cancers (DPA, cervical carcinoma, and head and neck cancer). We further show that this germ cell-like transcriptional program, even when reduced to the top two genes (CDKN2A and SYCP2), serves as a fingerprint of oncogenic HPVs with implications for early detection, diagnosis, and therapy of all HPV-driven cancers.SignificanceWe identify HPV42 as a uniform driver of DPA and add a new member to the short list of tumorigenic viruses in humans. We discover that all oncogenic HPVs evoke a germ cell-like transcriptional program with important implications for detecting, diagnosing, and treating all HPV-driven cancers. See related commentary by Starrett et al., p. 17. This article is highlighted in the In This Issue feature, p. 1.

| S-EPMC9827110 | biostudies-literature

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