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Role of TNFRSF13B (CD267) in prostate cancer progression identified via genetic analysis

ABSTRACT: Role of TNFRSF13B (CD267) in prostate cancer progression identified via genetic analysis

PROVIDER: PRJNA807157 | ENA |

REPOSITORIES: ENA

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Role of TNFRSF13B (CD267) in prostate cancer progression identified via genetic analysis

Project description:We performed microarray analysis using differnt prostate cancer cell lines (PC3 and 22RV1) after TNFRSF13B (CD267) knockdown. We reported that TNFRSF13B regulates cell cycle-associated genes and P53 signaling pathway in PC3 and 22RV1 cells.

2024-02-15 | GSE196746 | GEO

Identifying the role of MTHFD1L in prostate cancer progression from genetic analysis and experimental validation

Project description:One-carbon metabolism plays a crucial role in tumorigenesis as it supplies the one-carbon units necessary for nucleotide synthesis, epigenetic regulation, and redox metabolism, ensuring the rapid proliferation of cancer cells. However, their roles in prostate cancer progression remain poorly understood. In this study, we investigated the association between genetic variants in the one-carbon metabolism pathway and clinical outcomes in patients receiving androgen deprivation therapy for prostate cancer. The associations of 130 single-nucleotide polymorphisms located within 14 genes involved in the one-carbon metabolism pathway with cancer-specific survival (CSS), overall survival, and progression-free survival were assessed using Cox regression in 630 patients with prostate cancer. Subsequently, functional studies were performed using prostate cancer cell lines. After adjusting for covariates and multiple testing, MTHFD1L rs2073190 was found to be significantly associated with CSS (P = 0.000184). Further pooled analysis of multiple datasets demonstrated that MTHFD1L was upregulated in prostate cancer and increased MTHFD1L expression was positively correlated with tumor aggressiveness and poor patient prognosis. Functionally, MTHFD1L knockdown suppressed prostate cancer cell proliferation and colony formation. RNA sequencing and pathway analysis revealed that differentially expressed genes were predominantly enriched in the cell cycle pathway. In conclusion, genetic variants in MTHFD1L of one-carbon metabolism may serve as promising predictors, and our findings offer valuable insights into the underlying genetic mechanisms of prostate cancer progression.

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Elucidating the oncogenic role of Menin in prostate cancer progression

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Identifying the role of MTHFD1L in prostate cancer progression from genetic analysis and experimental validation

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Profiling of prostate tissues in prostate cancer progression

Project description:Samples of benign prostate tissue, localized prostate cancer tissue, and metastatic prostate cancer tissue are profiled to study expression changes in diagnosis and progression of prostate cancer. Each tissue sample is also profiled for metabolomics data Keywords: Cancer Progression 41 samples were analyzed (16 benign prostate tissue, 12 local prostate cancer tissue, 13 metastatic prostate cancer tissue)

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The Role of Uridine Glucuronosyl transferase 2B28 (UGT2B28) in Prostate Cancer Progression

Project description:The Role of Uridine Glucuronosyl transferase 2B28 (UGT2B28) in Prostate Cancer Progression

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Role for AP-1 transcription factors (c-Jun, c-Fos) in prostate cancer progression and clinical outcome of prostate tumor

Project description:In our investigations of the molecular pathways of prostate tumorigenesis in Nkx3.1; Pten mutant mice using gene expression profiling, we now find that the AP-1 transcription factors, c-Jun and c-Fos, are significantly up-regulated during cancer progression. Forced expression of c-Fos and c-Jun in prostate cancer cells results in increased tumorigenicity, activation of Erk MAP kinase, and enhanced survival in the absence of androgens, which are hallmarks of disease progression. In humans, Jun and Fos proteins are significantly up-regulated during prostate cancer progression and significantly correlated with activation of Erk MAP kinase. Most notably, expression of Jun is associated with disease recurrence independent of other currently used prognostic indicators. These analyses reveal a hitherto unappreciated role for AP-1 transcription factors in prostate cancer progression vis-à-vis Erk MAP kinase signaling, as well as the identification of a novel marker of disease recurrence, namely c-Jun. Keywords: Stages of Prostate Cancer

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The Role of Uridine Glucuronosyl transferase 2B28 (UGT2B28) in Prostate Cancer Progression [day30]

Project description:The Role of Uridine Glucuronosyl transferase 2B28 (UGT2B28) in Prostate Cancer Progression [day30]

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Cancer associated fibroblasts play an important role in prostate cancer progression [RNA-Seq]

Project description:Cancer associated fibroblasts play an important role in prostate cancer progression [RNA-Seq]

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