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ABSTRACT: Biological characteristics and transcriptome analysis of Serangium japonicum fed Corcyra cephalonica eggs as an alternate food

PROVIDER: PRJNA808409 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18079455_1.fastq.gz	Fastqsanger.gz
	SRR18079455_2.fastq.gz	Fastqsanger.gz
	SRR18079456_1.fastq.gz	Fastqsanger.gz
	SRR18079456_2.fastq.gz	Fastqsanger.gz
	SRR18079457_1.fastq.gz	Fastqsanger.gz

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S.japonicum Digital Gene Expression

Project description:Schistosoma japonicum is one of the remarkable platyhelminths that are endemic in the South Asian countries. The parasite is dioecious and can parasitize inside host blood stream for many years. Rapid reproduction by producing large number of eggs and count-react or active manipulating host anti-parasite responses are the strategies that benefit the long term parasitization of the parasite. Currently, Praziquantel is the only commercial drug that is effective against the worms but not the eggs of parasite in the host and no vaccine available to prevent human or animal schistosomiasis. Development of novel antiparasite reagents and immune-prevention measures rely on the deciphering of parasite biology. The decoding of the genomic sequence of the parasite has made it possible to dissect the biological functions of genes that govern the development of the parasite inside the hosts. In this study, the polyadenylated RNA from male and female S. japonicum was isolated and deep sequenced. By comparative analysis on the transcriptomic differences of the two sexes of the parasite, potential genes or gender-specific biological pathways can be targeted.

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Qualitative and Quantitative proteomic analyses of Schistosoma japonicum Eggs and Egg-derived Secretory-Excretory proteins

Project description:Schistosome parasites lay up to a thousand eggs per day inside the veins of their mammalian hosts. The immature eggs deposited by females against endothelia of venules will embryonate within days. Approximately 30% of the eggs will migrate to the lumen of the intestine to continue the parasite life cycle. Many eggs, however, are trapped in the liver and intestine causing the main pathology associated with schistosomiasis mansoni and japonica, the liver granulomatous response. Excretory/Secretory egg proteins drive much of egg-induced pathogenesis of schistosomiasis mansoni, and Schistosoma japonicum induce a markedly distinct granulomatous response to that of S. mansoni.

2019-09-26 | PXD012835 | Pride

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