Project description:Imipenem-relebactam resistance in KPC-producing Klebsiella pneumoniae
| PRJNA869900 | ENA
Project description:Induced resistance to imipenem-relebactam in KPC-producing Klebsiella pneumoniae
| PRJNA762266 | ENA
Project description:In vivo emergence of Imipenem/relebactam resistance in KPC-producing Klebsiella pneumoniae mediated by increased blaKPC copy number and porins
| PRJNA794363 | ENA
Project description:Activity of imipenem/relebactam against KPC-producing Klebsiella pneumoniae and the role of Ompk36 mutation in determining resistance: an Italian retrospective analysis
Project description:The inappropriate use of antibiotics is a severe public health problem worldwide, contributing to the emergence of multidrug-resistant (MDR) bacteria. To explore the possible impacts of the inappropriate use of antibiotics on the immune system, we use Klebsiella pneumoniae (K. pneumoniae) infection as an example and show that imipenem increases the mortality of mice infected by MDR K. pneumoniae. Further studies demonstrate that imipenem enhances the secretion of outer membrane vesicles (OMVs) with significantly elevated presentation of GroEL, which promotes the phagocytosis of OMVs by macrophages that depends on the interaction between GroEL and its receptor LOX-1. OMVs cause the pyroptosis of macrophages and the release of proinflammatory cytokines, which contribute to exacerbated inflammatory responses. We propose that the inappropriate use of antibiotics in the cases of infection by MDR bacteria such as K. pneumoniae might cause damaging inflammatory responses, which underlines the pernicious effects of inappropriate use of antibiotic.
