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ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection II

ABSTRACT: ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection II

PROVIDER: PRJNA812586 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18214213.fastq.gz	Fastqsanger.gz
	SRR18214214.fastq.gz	Fastqsanger.gz
	SRR18214215.fastq.gz	Fastqsanger.gz
	SRR18214216.fastq.gz	Fastqsanger.gz

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Similar Datasets

ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection II

Project description:In this study, we define ZBTB7A as a driver of cellular survival during HCoV-229E infection.

2022-10-05 | GSE197882 | GEO

ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection I

Project description:In this study, we define ZBTB7A as a driver of cellular survival during HCoV-229E infection.

2022-10-05 | GSE197644 | GEO

ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection

Project description:ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection

| PRJNA812582 | ENA

ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection I

Project description:ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection I

| PRJNA811447 | ENA

ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection.

Project description:The cellular fate after infection with human coronaviruses (HCoVs) is typically death. Previous data suggest, however, that the transcriptional state of an individual cell may sometimes allow additional outcomes of infection. Here, to probe the range of interactions a permissive cell type can have with a HCoV, we perform a CRISPR activation screen with HCoV-229E. The screen identified the transcription factor ZBTB7A, which strongly promotes cell survival after infection. Rather than suppressing viral infection, ZBTB7A upregulation allows the virus to induce a persistent infection and homeostatic state with the cell. We also find that control of oxidative stress is a primary driver of cellular survival during HCoV-229E infection. These data illustrate that, in addition to the nature of the infecting virus and the type of cell that it encounters, the cellular gene expression profile prior to infection can affect the eventual fate.

| S-EPMC9533670 | biostudies-literature

ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-10-05 | GSE197883 | GEO

Human Primary Airway Epithelium Response to HCoV-229E Infection

Project description:The purpose of this experiment was to evaluate the human host cellular response to wild-type Human coronavirus strain 229E (HCoV-229E) infection. Sample data was obtained for mock and infected (MOI 3) primary human airway epithelial cells grown in air-liquid interface conditions, processed for RNA sequencing (RNA-Seq) expression analysis.

2025-10-01 | GSE279463 | GEO

Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors

Project description:The ongoing SARS-CoV-2 pandemic has devastated the global economy and claimed more than one million lives, presenting an urgent global health crisis. To identify host factors required for infection by SARS-CoV-2 and seasonal coronaviruses, we designed a focused high-coverage CRISPR-Cas9 library targeting 332 members of a recently published SARS-CoV-2 protein interactome. We leveraged the compact nature of this library to systematically screen SARS-CoV-2 at two physiologically relevant temperatures (33 ºC and 37 ºC) along with three related coronaviruses (HCoV-229E, HCoV-NL63, and HCoV-OC43), allowing us to probe this interactome at a much higher resolution relative to genome scale studies. This approach yielded several new insights, including unexpected virus-specific differences in Rab GTPase requirements and GPI anchor biosynthesis, as well as identification of multiple pan-coronavirus factors involved in cholesterol homeostasis. This coronavirus essentiality catalog could inform ongoing drug development efforts aimed at intercepting and treating COVID-19, and help prepare for future coronavirus outbreaks.

2020-11-24 | GSE162039 | GEO

Human A549 and MRC5 Cell Response to HCoV-229E Infection

Project description:The purpose of this experiment was to evaluate the human host cellular response to wild-type Human coronavirus strain 229E (HCoV-229E) infection. Sample data was obtained for mock and infected (MOI 5) immortalized human lung epithelial cells (A549) and immortalized human lung fibroblasts cells (MRC5) processed for RNA sequencing (RNA-Seq) expression analysis.

2025-10-01 | GSE279271 | GEO

Genome-scale CRISPR knockout screen for Dengue, Japanese Encephalitis, and Human Coronavirus 229E viruses

Project description:Unbiased forward genetic screens to identify host factors for DENV1 and JEV in 293FT cells. Unbiased forward genetic screens to identify host factors for HCoV-229E in Huh7.5.1 cells.

2024-09-13 | E-MTAB-13751 | biostudies-arrayexpress

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