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CircRAB3IP modulates cell proliferation by reorganizing gene expression and mRNA processing in a paracrine manner [HEK293_KD]

ABSTRACT: circRAB3IP modulates cell proliferation by reorganizing gene expression and mRNA processing in a paracrine manner [HEK293_KD]

PROVIDER: PRJNA820719 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18503776_1.fastq.gz	Fastqsanger.gz
	SRR18503776_2.fastq.gz	Fastqsanger.gz
	SRR18503777_1.fastq.gz	Fastqsanger.gz
	SRR18503777_2.fastq.gz	Fastqsanger.gz
	SRR18503778_1.fastq.gz	Fastqsanger.gz

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circRAB3IP modulates cell proliferation by reorganizing gene expression and mRNA processing in a paracrine manner

Project description:circRAB3IP modulates cell proliferation by reorganizing gene expression and mRNA processing in a paracrine manner

| PRJNA820712 | ENA

circRAB3IP modulates cell proliferation by reorganizing gene expression and mRNA processing in a paracrine manner [HUVEC_KD]

Project description:circRAB3IP modulates cell proliferation by reorganizing gene expression and mRNA processing in a paracrine manner [HUVEC_KD]

| PRJNA820718 | ENA

circRAB3IP modulates cell proliferation by reorganizing gene expression and mRNA processing in a paracrine manner [HUVEC_EVs_OE]

Project description:circRAB3IP modulates cell proliferation by reorganizing gene expression and mRNA processing in a paracrine manner [HUVEC_EVs_OE]

| PRJNA820717 | ENA

circRAB3IP modulates cell proliferation by reorganizing gene expression and mRNA processing in a paracrine manner.

Project description:Circular RNAs are an endogenous long-lived and abundant noncoding species. Despite their prevalence, only a few circRNAs have been dissected mechanistically to date. Here, we cataloged nascent RNA-enriched circRNAs from primary human cells and functionally assigned a role to circRAB3IP in sustaining cellular homeostasis. We combined "omics" and functional experiments to show how circRAB3IP depletion deregulates hundreds of genes, suppresses cell cycle progression, and induces senescence-associated gene expression changes. Conversely, excess circRAB3IP delivered to endothelial cells via extracellular vesicles suffices for accelerating their division. We attribute these effects to an interplay between circRAB3IP and the general splicing factor SF3B1, which can affect transcript variant expression levels of cell cycle-related genes. Together, our findings link the maintenance of cell homeostasis to the presence of a single circRNA.

| S-EPMC9745835 | biostudies-literature

circRAB3IP modulates cell proliferation by reorganizing gene expression and mRNA processing in a paracrine manner

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-03-30 | GSE199553 | GEO

The matricellular protein Fibulin-5 regulates β-cell proliferation in an autocrine/paracrine manner

Project description:The matricellular protein Fibulin-5 regulates β-cell proliferation in an autocrine/paracrine manner

| PRJNA601160 | ENA

circRAB3IP modulates cell proliferation by reorganizing gene expression and mRNA processing in a paracrine manner [HUVEC_KD]

Project description:Circular RNAs are endogenous long-lived and abundant non-coding species. Despite their prevalence, only few circRNAs have been dissected mechanistically as regards their function to date. Here, we catalogued nascent RNA-enriched circRNAs from primary human cells and focus on circRAB3IP to assign to it a role in sustaining cellular homeostasis. We combine “omics” and functional experiments to show how circRAB3IP depletion deregulates hundreds of genes, suppress cell cycle progression, and brings about senescence-like gene expression changes. Conversely, excess circRAB3IP delivered to endothelial cells via exosomes suffices for accelerating their cell division. We attribute these effects to widespread changes in isoform usage that stem from the interplay between circRAB3IP and the general splicing factor SF3B1. Together, our findings link the maintenance of cell homeostasis to the tightly regulated titers of a single circRNA.

2022-03-30 | GSE199551 | GEO

circRAB3IP modulates cell proliferation by reorganizing gene expression and mRNA processing in a paracrine manner [HEK293_KD]

2022-03-30 | GSE199550 | GEO

circRAB3IP modulates cell proliferation by reorganizing gene expression and mRNA processing in a paracrine manner [HUVEC_EVs_OE]

2022-03-30 | GSE199552 | GEO

The matricellular protein Fibulin-5 regulates β-cell proliferation in an autocrine/paracrine manner

Project description:The matricellular protein Fibulin-5 (Fbln5) is a secreted protein that is essential for elastic fiber formation, and pancreatic islets are usually surrounded by the extracellular matrix (ECM), which includes elastic fibers. However, much uncertainty remains regarding the function of the ECM and its components in β-cells. Here, we describe the role of Fbln5 in β-cell replication. Fbln5 expression was increased upon glucose stimulation in β-cells of mouse and human islets. β-Cell-specific Fbln5-knockout (βFbln5KO) mice exhibit significantly reduced β-cell proliferation in vivo but not in vitro. Secreted extracellular Fbln5 enhances β-cell replication. Fbln5-deficient β-cells exhibit downregulated expression of the gene encoding polo-like kinase 1 (PLK1), which is accompanied by ERK-mediated FoxM1 nuclear export. These data suggest that Fbln5 is secreted from β-cells in response to glucose and plays important roles in the appropriate maintenance of β-cell functions in an autocrine or paracrine manner.

2024-11-19 | GSE143633 | GEO

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