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Hippocampal RNA-seq in mice selectively bred for high and low open-field activity (OFA)

ABSTRACT: Hippocampal RNA-seq in mice selectively bred for high and low open-field activity (OFA)

PROVIDER: PRJNA822785 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18588200_1.fastq.gz	Fastqsanger.gz
	SRR18588200_2.fastq.gz	Fastqsanger.gz
	SRR18588201_1.fastq.gz	Fastqsanger.gz
	SRR18588201_2.fastq.gz	Fastqsanger.gz
	SRR18588202_1.fastq.gz	Fastqsanger.gz

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Hippocampal RNA-seq in mice selectively bred for high and low open-field activity (OFA)

Project description:Purpose: To investigate the effect that selective breeding for high and low OFA has on gene expression Methods: Male and female High and Low Activity mice (n=4 per strain/sex) were euthanized at postnatal day 70 and hippocampi were immediately collected. Paired-end RNA-seq methods were employed to assess hippocampal mRNA expression. Results: The expression of thousands of transcripts were altered by selective breeding for high and low OFA.

2022-10-01 | GSE200043 | GEO

Hippocampal RNA-Seq Data and Behavioral Data from Rats Selectively-Bred to Show High or Low Levels of Locomotor Activity in a Novel Environment (bred High Responders vs. bred Low Responders)

Project description:Using selective breeding, we have produced two rat lines with highly contrasting heritable behaviors: bred Low Responders (bLR) are extremely inhibited and anxious in a novel environment, whereas bred High Responders (bHR) are exploratory and sensation-seeking. These traits map onto temperamental extremes predictive of internalizing vs. externalizing psychiatric disorders in humans and can model two divergent paths to drug abuse. To elucidate gene expression underlying these behavioral extremes, bHRxbLR were bred to produce a F0-F1-F2 cross. We then measured exploratory locomotion, anxiety-like behavior, and sensitivity to reward cues (Pavlovian Conditioned Approach) and performed hippocampal RNA sequencing in both F0s (n=24, n=6/phenotype/sex) and F2s (n=250, n=125/sex). The data included in this GEO upload is the data from the F0s from this experiment.

2025-02-07 | GSE225744 | GEO

Hippocampal RNA-Seq Data and Behavioral Data from an F2 intercross of Rats Selectively-Bred to Show High or Low Levels of Locomotor Activity in a Novel Environment (bred High Responders vs. bred Low Responders)

2025-02-07 | GSE225746 | GEO

Hippocampal Gene Expression in bred High Responder (bHR) vs. bred Low Responder (bLR) Rats: RNA-Seq Data from Generation F37

Project description:The strong pattern of comorbidity amongst psychiatric disorders is believed to be generated by a spectrum of latent liability, arising from a complex interplay of genetic risk and environmental factors, such as stress and childhood adversity. At one end of this spectrum are internalizing disorders, which are associated with neuroticism, anxiety, and depression. At the other end of the spectrum are externalizing disorders, which are associated with risk-taking and novelty-seeking, as seen in mania, substance abuse, and impulse-control disorders. We model the genetic contributions underlying both extremes of this spectrum by selectively breeding rats that react differently to a novel environment. “Bred high responder” (bHR) rats are highly exploratory with a disinhibited, novelty-seeking temperament, including hyperactivity, aggression, and drug-seeking. “Bred low responder” (bLR) rats are highly-inhibited, exhibiting reduced locomotor activity and anxious and depressive-like behavior. These behavioral propensities are robust and stable, beginning early in development similar to temperament in humans. This RNA-sequencing study examined gene expression in the hippocampus, a region critical for emotional regulation, in generation F37 adult male bHR rats and bLR rats (n=6/group), as well as in rats that showed an intermediate locomotor response to a novel field (“bred Intermediate Responder” or bIR rats, n=6), which were obtained by cross-breeding F37 bHR and bLR rats. Prior to sacrifice, the animals experienced behavioral testing. Locomotor response to a novel environment was assessed between age P50–75 as part of our selective breeding paradigm. We also measured anxiety-like behavior in adulthood (bHR/bLR: P160-P167; bIR: P65-75) using the percent time spent in the open arms of an Elevated Plus Maze (EPM; 5 min test). These behavioral testing results are provided here along with the gene expression data.

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Hippocampal Gene Expression in bred High Responder (bHR) vs. bred Low Responder (bLR) Rats

Project description:Hippocampal Gene Expression in bred High Responder (bHR) vs. bred Low Responder (bLR) Rats

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Hippocampal RNA-Seq Data and Behavioral Data from Rats Selectively-Bred to Show High or Low Levels of Locomotor Activity in a Novel Environment (bred High Responders vs. bred Low Responders)

Project description:Hippocampal RNA-Seq Data and Behavioral Data from Rats Selectively-Bred to Show High or Low Levels of Locomotor Activity in a Novel Environment (bred High Responders vs. bred Low Responders)

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Comparison of Differences in Gene Expression in brain of 5 Pairs of Rat Lines Selectively Bred for High or Low Alcohol Consumption

Project description:This SuperSeries is composed of the following subset Series: GSE31695: Comparison of Differences in Gene Expression in the Ventral Tegmental Area of 5 Pairs of Rat Lines Selectively Bred for High or Low Alcohol Consumption GSE31705: Comparison of Differences in Gene Expression in the Nucleus Accumbens Shell of 5 Pairs of Rat Lines Selectively Bred for High or Low Alcohol Consumption GSE31708: Comparison of Differences in Gene Expression in the Central Nucleus of the Amygdala (CeA) of 5 Pairs of Rat Lines Selectively Bred for High or Low Alcohol Consumption Refer to individual Series

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Comparison of whole brain expression data between selectively bred P and NP, alcohol naïve rats

Project description:Gene expression was analyzed in brains of 4 male selectively-bred alcohol-preferring (P) rats (generation 63) and 3 male alcohol non-preferring (NP) rats (generation 62) that were obtained from Dr. Richard L. Bell, Indiana University School of Medicine, Indianapolis, IN. These rats had never been exposed to alcohol.

2011-04-19 | GSE15764 | GEO

Project description:Hippocampal RNA-Seq Data and Behavioral Data from an F2 intercross of Rats Selectively-Bred to Show High or Low Levels of Locomotor Activity in a Novel Environment (bred High Responders vs. bred Low Responders)

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Rattus norvegicus albus breed:Selectively bred alcohol-preferring (P) and nonpreferring (NP)

Project description:RNAseq of selectively bred alcohol-preferring (P) and nonpreferring (NP) rats

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