Dataset Information

Mrgpra1 controls neutrophil hyperactivation by balancing N1/N2 switch

ABSTRACT: Mrgpra1 controls neutrophil hyperactivation by balancing N1/N2 switch

PROVIDER: PRJNA823687 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18645026.fastq.gz	Fastqsanger.gz
	SRR18645027.fastq.gz	Fastqsanger.gz
	SRR18645028.fastq.gz	Fastqsanger.gz
	SRR18645029.fastq.gz	Fastqsanger.gz
	SRR18645030.fastq.gz	Fastqsanger.gz

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Project description:Periodontitis is a chronic non-communicable disease caused by dysbiotic changes that affect the subgingival microbiota. During periodontitis, neutrophils play a central role in the initial recognition of bacteria, and their number increases with the appearance of the first signs of periodontal inflammation. Recent evidence has led to the proposition that neutrophils can also functionally polarize, determining selective activity patterns related to different diseases. Two well-defined neutrophil phenotypes have been described, the pro-inflammatory N1 subset and the suppressor N2 subset. To date, it has not been established whether these different neutrophil subtypes play a role in the pathogenesis of periodontitis. Thus, this scoping review aimed to determine whether there was evidence to suggest that the neutrophils present in periodontal tissues can be associated with certain phenotypes. The research question, population, concept, and context sought to identify original articles, in humans, that detected the presence of neutrophils in the periodontal tissues of people affected by periodontitis. Based on the search strategy, we found 3658 studies. After removing the papers with abstracts not related to the outcome measures and eligibility criteria, 16 articles were included for qualitative analysis. Several studies identified the presence of different neutrophil subsets, specifically, the naive, pro- and para-inflammatory, hyper-reactive and hyper-active, and high- and low-responder phenotypes. The existing evidence demonstrates the presence of pro-inflammatory, hyper-reactive and high-responder neutrophils in periodontal tissues affected with periodontitis. There is no evidence demonstrating the presence of the N1 or N2 phenotypes in periodontal tissues during periodontitis. However, the existence of pro-inflammatory phenotypes, which increase NETosis and degranulation, and increase the production of pro-inflammatory cytokines, could be suggestive of the N1 phenotypes.

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Mrgpra1 controls neutrophil hyperactivation by balancing N1/N2 switch

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