Project description:Polycystic ovary syndrome (PCOS) is a multifactorial disorder closely associated with metabolic dysfunction, yet the contribution of gut microbiota–derived metabolites remains incompletely understood.
2026-06-09 | GSE328499 | GEO
Project description:Microbiome in polycystic ovary syndrome
Project description:Background: Polycystic ovary syndrome is associated with metabolic and hormonal disturbances during pregnancy, but whether these alterations are reflected in the fetal intrauterine exposure environment remains incompletely understood. This study aimed to identify polycystic ovary syndrome-related intrauterine metabolic signatures using late-gestation amniotic fluid. Methods: Untargeted metabolomic profiling was performed on late-gestation amniotic fluid samples from women with polycystic ovary syndrome and controls. Differential metabolite analysis, pathway-level analysis, and multilevel sensitivity analyses were conducted to identify robust metabolic alterations associated with maternal polycystic ovary syndrome. Exploratory placental transcriptomic analysis was further used to provide tissue-level evidence for lipid-related metabolic alterations.
2026-07-25 | MTBLS14946 | MetaboLights
Project description:Gut microbiota characteristics of obese Polycystic ovary syndrome patients
