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Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment [scRNA-seq]

ABSTRACT: Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment [scRNA-seq]

PROVIDER: PRJNA825379 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18709106_1.fastq.gz	Fastqsanger.gz
	SRR18709106_2.fastq.gz	Fastqsanger.gz
	SRR18709107_1.fastq.gz	Fastqsanger.gz
	SRR18709107_2.fastq.gz	Fastqsanger.gz
	SRR18709108_1.fastq.gz	Fastqsanger.gz

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Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment [scRNA-seq]

Project description:Immune cells must adapt to different environments during an immune response. We studied the adaptation of CD8+ T cells to the intestinal microenvironment and how this process shapes tissue resident CD8+ T cells (TRM) in the gut. CD8+ T cells progressively remodel their transcriptome and surface phenotype as they acquire gut residency, and downregulate mitochondrial gene expression. Human and mouse gut-resident CD8+ T cells have reduced mitochondrial mass, but maintain a viable energy balance to sustain function. We found that the intestinal microenvironment is rich in prostaglandin E2 (PGE2), which drives mitochondrial depolarization in CD8+ T cells. Consequently, they engage autophagy to clear depolarized mitochondria, and enhance glutathione synthesis to scavenge reactive oxygen species (ROS). Impairing PGE2 sensing promotes TRM accumulation, while tampering with autophagy and glutathione negatively impacts the TRM pool. Thus, a PGE2-autophagy-glutathione axis defines the metabolic adaptation of CD8+ T cells to the intestinal microenvironment, to ultimately influence the TRM pool.

2023-11-27 | GSE200567 | GEO

Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment [RNA-seq]

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Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment.

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Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment [RNA-seq]

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Spleen vs Prostaglandin E2 Treated B cell

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Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment.

Project description:This SuperSeries is composed of the SubSeries listed below.

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Enhanced cardiac reprogramming by Inhibition of cyclooxygenase-2/prostaglandin E2/prostaglandin E receptor 4 signaling

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