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Effect of depletion of NUP153 on gene expression in esophageal squamous cell carcinoma cell line TE5 cells [RNA-seq]

ABSTRACT: Effect of depletion of NUP153 on gene expression in esophageal squamous cell carcinoma cell line TE5 cells [RNA-seq]

PROVIDER: PRJNA826343 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18740843_1.fastq.gz	Fastqsanger.gz
	SRR18740843_2.fastq.gz	Fastqsanger.gz
	SRR18740844_1.fastq.gz	Fastqsanger.gz
	SRR18740844_2.fastq.gz	Fastqsanger.gz
	SRR18740845_1.fastq.gz	Fastqsanger.gz

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Effect of depletion of NUP153 on gene expression in esophageal squamous cell carcinoma cell line TE5 cells [RNA-seq]

Project description:To investigate the function NUP153 in the regulation of cancer cell biology, we established TE5 cell lines in which NUP153 gene has been knocked down by shRNA.

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Nucleoporin Nup153 Regulates Stem Cell Pluripotency through Gene Silencing

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Project description:We konckout PARK2 in Esophageal Squamous Cell Cancer Cell Line EC9706 and then detected differentially expressed genes We konckout PARK2 in Esophageal Squamous Cell Cancer Cell Line EC9706 and then detected differentially expressed genes

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Association of NUP153 on genomic DNA in TE5 cells [ChIP-seq]

Project description:Association of NUP153 on genomic DNA in TE5 cells [ChIP-seq]

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Nup153 defines neural identity through cooperative transcriptional control with Sox2

Project description:Through RNA interference and genome-wide Nup153 binding studies, we found that Nup153 and Sox2 bind and co-regulate hundreds of genes. Furthermore, we found that Nup153 exhibits binding location dependent spatially distinct transcriptional control by differentially regulating expression when bound to the promoter region or to the transcription end site (TES). These results establish Nup153 not only as a novel transcriptional co-regulator of Sox2 but also as a key player in the regulation of cell fate by directly modulating gene expression.

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