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Increased risk of mammary cancer recurrence in socially isolated rats is linked to upregulation of IL6/JAK/STAT3 and inhibition of oxidative phosphorylation signaling, activities blocked by the herbal mixture Jaeumganghwa-tang

ABSTRACT: Increased risk of mammary cancer recurrence in socially isolated rats is linked to upregulation of IL6/JAK/STAT3 and inhibition of oxidative phosphorylation signaling, activities blocked by the herbal mixture Jaeumganghwa-tang

PROVIDER: PRJNA828455 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18832851_1.fastq.gz	Fastqsanger.gz
	SRR18832851_2.fastq.gz	Fastqsanger.gz
	SRR18832852_1.fastq.gz	Fastqsanger.gz
	SRR18832852_2.fastq.gz	Fastqsanger.gz
	SRR18832853_1.fastq.gz	Fastqsanger.gz

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Increased risk of mammary cancer recurrence in socially isolated rats is linked to upregulation of IL6/JAK/STAT3 and inhibition of oxidative phosphorylation signaling, activities blocked by the herbal mixture Jaeumganghwa-tang

Project description:While multifactorial in origin, one of the most prevalent and impactful consequences of social isolation is an increase in cancer mortality. Using a preclinical model in Sprague Dawley rats, we found that social isolation increased the risk of mammary tumor recurrence after completion of antiestrogen therapy. The increased recurrence risk was associated with an upregulation of IL6/JAK/STAT3 signaling in the mammary glands and tumors and suppression of mitochondrial oxidative phosphorylation (OXPHOS) pathway. Also inhibited were genes involved in mitochondrial pyruvate transport and the conversion of pyruvate to acetyl CoA but lactate levels were not altered. In addition, social isolation increased the expression of receptor for advanced glycation end-products (RAGE), consistent with the impaired insulin sensitivity and weight gain linked to social isolation. All these changes are commonly associated with aging. In socially isolated animals consumption of the anti-inflammatory 12 herb mixture Jaeumganghwa-tang (JGT) inhibited IL6/JAK/STAT3 signaling, upregulated OXPHOS signaling, suppressed expression of the RAGE ligands S100a8 and S100a9, and prevented the increased risk of mammary cancer recurrence. In summary, increased breast cancer mortality among socially isolated survivors may be most effectively prevented by focusing on the period following the completion of endocrine therapy using tools that inhibit IL6/JAK/STAT3 inflammatory cytokine signaling and reverse disrupted OXPHOS.

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MDMs Solvent, AA, IL6, AA+IL6

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Bojungikki-tang ameliorates psoriasis-like dermatitis: Network analysis and transcriptomics with experimental validation

Project description:Psoriasis is a chronic and complex disease characterized by itching, burning, and soreness with scaly plaques and erythematous lesions. we evaluated the effect of Bojungikki-tang (BJT, Buzhong-Yiqi-Tang in traditional Chinese medicine and Hochu-ekki-to in Kampo medicine) as a combination of medicinal herbs against psoriasis. Network analysis from transcriptomics was used to determine the effective phytochemical constituents of BJT.

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Fermentation of Danggui Buxue Tang, an ancient Chinese herbal mixture, together with <i>Lactobacillus plantarum</i> enhances the anti-diabetic functions of herbal product.

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