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A honeybee stinger inspired self-interlocking microneedle patch and its application in myocardial infarction treatment

ABSTRACT: A honeybee stinger inspired self-interlocking microneedle patch and its application in myocardial infarction treatment

PROVIDER: PRJNA829729 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18846643_1.fastq.gz	Fastqsanger.gz
	SRR18846643_2.fastq.gz	Fastqsanger.gz
	SRR18846644_1.fastq.gz	Fastqsanger.gz
	SRR18846644_2.fastq.gz	Fastqsanger.gz
	SRR18846645_1.fastq.gz	Fastqsanger.gz

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A honeybee stinger inspired self-interlocking microneedle patch and its application in myocardial infarction treatment

Project description:Microneedle patches are widely employed in pain-free drug delivery, biosensing, and cosmetic applications. However, weak tissue adhesion remains a major challenge in clinical translation of microneedle patches. Here, mimicking the structural features of honeybee stingers, stiff polymeric microneedles with unidirectionally backward facing barbs were fabricated and embedded into various elastomer films to produce self-interlocking microneedle patches. The spirality of the barbing pattern was adjusted to increase interlocking efficiency. In the challenging working condition of animal hearts beat with large cyclic strains, the barbs provided 0.4 N interlocking force, which resulted in firm fixation of the bioinspired microneedle patch. In addition, the minimal bleeding caused by microneedle puncturing adhered the porous surface of the patch substrate between microneedles to the epicardium via coagulation. In the demonstrative application of myocardial infarction treatment, the microneedle patches significantly reduced cardiac wall stress and strain in the infarct and border zone, maintaining left ventricular function and morphology. In addition, the microneedle patch was minimally invasively implanted onto beating porcine heart free of sutures and adhesives, and the fixation step only took 2 minutes. Therefore, the honeybee stinger inspired microneedles could provide an adaptive and convenient means to adhere patches for various medical applications.

2023-01-01 | GSE201196 | GEO

Epicardial transplantation of antioxidant polyurethane scaffold based human amniotic epithelial stem cell patch for myocardial infarction treatment

Project description:Myocardial infarction (MI) is a leading cause of death globally. Stem cell therapy is considered a potential strategy for MI treatment. Transplantation of classic stem cells including embryonic, induced pluripotent and cardiac stem cells exhibited certain repairing effect on MI via supplementing cardiomyocytes, however, their clinical applications were blocked by problems of cell survival, differentiation, functional activity and also biosafety and ethical concerns. Here, we introduced human amniotic epithelial stem cells (hAESCs) featured with immunomodulatory activities, immune-privilege and biosafety, for constructing a stem cell cardiac patch based on porous antioxidant polyurethane (PUR), which demonstrated decent hAESCs compatibility. In rats, the administration of PUR-hAESC patch significantly reduced fibrosis and facilitated vascularization in myocardium after MI and consequently improved cardiac remodeling and function. Mechanistically, the patch facilitated a desirable immune response for cardiac repair, framing the infiltration of neutrophils and inflammatory macrophages. Our findings may provide a potential therapeutic strategy for MI.

2024-07-18 | GSE237527 | GEO

Biologically-inspired melt electrowriting for the generation of highly biomimetic functional myocardium

Project description:In the heart, the specific 3D structure of myocardial layers produces an efficient ejection of blood. When myocardial infarction strikes, this architecture is disrupted, adding a disarranged contraction to the decreased availability of pumping units (cardiomyocytes, CMs). In this work, we characterize the alignment of cardiac fibers in a large animal model (pig) and employ melt electrowriting (MEW) to fabricate a bio-inspired scaffold with diamond-shaped pores. Using human induced pluripotent stem cell-derived CMs and cardiac fibroblasts, we generate human cardiac tissues with a biomimetic in-plane contraction. Our tissues beat macroscopically for over one month, with significantly faster kinetics, increased force and higher conduction velocity than those based on square or rectangular pores. Our diamond design induces a specific hiPSC-CM alignment resulting in the observed in-plane contraction. Transcriptomic analysis using bulk RNA-seq reveals diamond-MEW tissues present features of maturation as compared to traditional 2D cultures. Finally, we employ the bio-inspired cardiac tissues to treat an infarction model in athymic rats, showing a significant benefit on systolic function and remodeling, tied to the presence of large grafts of human cells remuscularizing the ventricular wall. All in all, we demonstrate that the new design generates superior human cardiac tissues with therapeutic capacity.

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honeybee metagenome

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Epicardial transplantation of antioxidant polyurethane scaffold based human amniotic epithelial stem cell patch for myocardial infarction treatment

Project description:Epicardial transplantation of antioxidant polyurethane scaffold based human amniotic epithelial stem cell patch for myocardial infarction treatment

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Biased gene expression in early honeybee larval development (microarray)

2013-11-13 | E-GEOD-52288 | biostudies-arrayexpress

The overall response of Paenibacillus larvae to bodily fluids of honeybee larvae (Apis mellifera).

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