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Small Intestinal Resident Eosinophils Maintain Gut Homeostasis Following Microbial Colonisation

ABSTRACT: Small Intestinal Resident Eosinophils Maintain Gut Homeostasis Following Microbial Colonisation

PROVIDER: PRJNA830974 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18899723.fastq.gz	Fastqsanger.gz
	SRR18899724.fastq.gz	Fastqsanger.gz
	SRR18899725.fastq.gz	Fastqsanger.gz
	SRR18899726.fastq.gz	Fastqsanger.gz
	SRR18899727.fastq.gz	Fastqsanger.gz

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Small Intestinal Resident Eosinophils Maintain Gut Homeostasis Following Microbial Colonisation

Project description:Intestinal homeostasis following postnatal microbial colonization requires the coordination of multiple processes, including the activation of immune cells, cell-cell communication, the controlled deposition of extracellular matrix, and epithelial cell turnover and differentiation. The intestine harbors the largest frequency of resident eosinophils of all homeostatic organs, yet the functional significance of eosinophil residence in the gut remains unclear. Eosinophils are equipped to both respond to, and modify, their local tissue environment and thus are able to regulate the adaption of tissues to environmental changes. We report a critical role for eosinophils in regulating villous structure, barrier integrity and motility in the small intestine. Notably, the microbiota was identified as a key driver of small intestinal eosinophil activation and function. Collectively our findings demonstrate a critical role for eosinophils in facilitating mutualistic interactions between host and microbiota and provide a rationale for the functional significance of their early life recruitment in the small intestine.

2025-08-27 | PXD032084 | Pride

Small Intestinal Resident Eosinophils Maintain Gut Homeostasis Following Microbial Colonisation

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Project description:Purpose: we aimed to characterized eosinophils in the murine model of asthma Methods: Eosinophils were sorted from the lung of naïve and and HDM-induced asthma mice. There after RNA was extracted from the sorted eosinophils and subjected to RNAseq. Results:we demonstrated that resident lung eosinophils require IL-5 for their survival and that the expression of Siglec-F, is regulated by IL-5 . Conclusion: Our data suggest that the distinct eosinophil populations in the asthmatic lung represent a continuum of activation states rather than distinct eosinophil subsets.

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Project description:Small Intestinal Resident Eosinophils Maintain Gut Homeostasis Following Microbial Colonisation

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M2-like dermis resident macrophages regulate type 1 2 circuitries with ILC2s and eosinophils to exacerbate cutaneous leishmaniasis

Project description:Tissue-resident macrophages (TRMs) are critical for tissue homeostasis/repair. We previously showed that dermal TRMs produce CCL24 which mediates their interaction with IL-4 producing eosinophils, required to maintain their M2-like properties in the TH1 environment of the Leishmania major infected skin. Here, we unveil another layer of TRM self-maintenance involving production of TSLP, an alarmin typically characterized as epithelial cell-derived. Both TSLP signaling and IL-5+ innate lymphoid cell 2 (ILC2s) were shown to maintain dermal TRM numbers and promote infection. Single cell RNA sequencing identified the dermal TRMs as the sole source of TSLP and CCL24. Generation of Ccl24-cre mice permitted specific labeling of dermal TRMs, as well as interstitial TRMs from other organs. Genetic ablation of TSLP from dermal TRMs reduced the number of dermal TRMs and ameliorated infection. Here, we show that by orchestrating localized type 2 circuitries with ILC2s and eosinophils, dermal TRMs are self-maintained as a replicative niche for L. major.

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Mouse resident lung eosinophils are dependent on IL-5

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Project description:Eosinophils Maintain Gut Homeostasis Following Microbial Colonisation

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