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Characterization of mast cells from human umbilical cord blood

ABSTRACT: Characterization of mast cells from human umbilical cord blood

PROVIDER: PRJNA831842 | ENA |

REPOSITORIES: ENA

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Characterization of mast cells from human umbilical cord blood

Project description:Mast cells are tissue-resident innate immune cells that express high affinity to receptor immunoglobulin E and responsible for host defense and array of diseases relate to immune system. We aim to characterize the function of human umbilical cord blood-dervied mast cells (hCBMCs).

2024-04-30 | GSE201473 | GEO

Effects of IL-4 conditioning on human umbilical cord blood-derived mast cells

Project description:This study evaluates the effects of 96h stimulus with Interleukin 4 (100 ng/mL) on the transcriptome of human umbilical cord blood derived mast cells. Through this approach, we identify upregulation of key intraepithelial mast cell-associated transcripts and downregulation of subepithelial mast cell-associated transcripts. Replicates are technical duplicates. Samples were sequenced on an Illumina NextSeq 500.

2021-01-30 | GSE165804 | GEO

Transcription profiling of human umbilical cord blood derived mast cells IgE sensitized followed by crosslinking receptor at different time points

Project description:Human umbilical cord blood derived mast cells IgE sensitized followed by crosslinking receptor at different time points

2008-06-11 | E-GEOD-1933 | biostudies-arrayexpress

Effects of IL-4 conditioning on human umbilical cord blood-derived mast cells

Project description:Effects of IL-4 conditioning on human umbilical cord blood-derived mast cells

| PRJNA697951 | ENA

Transcriptomic profiling of 27-year cryopreserved umbilical cord blood HSCs/HPCs

Project description:Umbilical cord blood banking is critical for the success of umbilical cord blood transplants. Here we analyzed transcriptomic differences between 27-year cryopreserved umbilical cord blood hematopoietic stem cells (HSCs) and multipotent progenitor cells (MPPs) and those derived from fresh cord blood. We also leveraged differences in engraftment capacity to examine the transcriptomes of HSCs/HPCs defined by engraftment capacity, demonstrating the feasibility of this approach for identifying potency markers to aid in the selection of cord blood units for transplantation and revealing novel potential regulators of cord blood HSC/HPC engraftment.

2023-10-04 | GSE225699 | GEO

Evolution of the Umbilical Cord Blood Proteome Across Gestational Development

Project description:Neonatal health is dependent on early risk stratification, diagnosis, and timely management of many potentially devastating conditions. Preterm infants are at increased risk of prematurity-related complications, including: early-onset sepsis, chronic lung disease, intraventricular hemorrhage, necrotizing enterocolitis, and neurodevelopmental impairment.Many of these conditions are poorly predicted in real-time by clinical data, including currently available diagnostic testing. Thus, biomarkers have been sought to aid early and targeted treatment and prognosis for these conditions. Umbilical cord blood may represent a novel source of molecular signatures that provides a window into the state of the fetus at birth. Umbilical cord blood inflammatory markers have been studied as diagnostic indicators of early-onset sepsis. Specific cord blood cytokines have been studied as predictors or correlates of retinopathy of prematurity, atopic disease, infantile hemangioma, placental histopathology, and more. However, few of these cord blood biomarkers have been translated into diagnostic tools in clinical practice. Longitudinal profiling of postnatal proteomic changes has provided insights into the development of the immune system over the first weeks to months of life. While proteomic profiling of cord blood has demonstrated immunologic differences between preterm and term infants, prior research has lacked inclusion of preterm infants across the continuum of gestational age and consideration of key perinatal characteristics such as the route of delivery, preeclampsia, intraamniotic infection, and neonatal sepsis that are likely to affect protein expression. In this study, we have comprehensively characterized the cord blood proteome from infants born between 25 to 42 weeks using MS to provide a benchmark of normative cord blood proteomic profile and examine proteome differences across the developmental range of gestational ages.

2025-05-06 | PXD051974 | Pride

Mast Cell_time series

Project description:Human umbilical cord blood derived mast cells IgE sensitized followed by crosslinking receptor at different time points Keywords: time-course

2006-08-21 | GSE1933 | GEO

Microarray comparison of adult peripheral blood megakaryocytes to umbilical cord blood-derived megakaryocytes

Project description:Primary adult peripheral blood (PB) megakaryocytes and umbilical cord blood (CB) megakaryocytes

2024-05-10 | GSE264384 | GEO

Human umbilical cord blood-derived mesenchymal stem cells from 2 donors

Project description:screening of signature deterimes the individual variations in the therapeutic efficacy of human umbilical cord blood-derived mesenchymal stem cells There is paucity of information whether human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) from separate donors might have different effects on improving myocardial repair after myocardial infarction (MI).

2011-02-19 | GSE27414 | GEO

Integrated Proteomic Characterization of Maternal Blood, Umbilical Cord Blood and Placenta Tissue of Gestational Diabetes Mellitus Patients

Project description:In this retrospective study, a diverse set of biological specimens was assembled, consisting of maternal blood, umbilical cord blood, and placenta tissue, from a cohort of 22 mothers with gestational diabetes mellitus and a matched group of 19 healthy mothers. Integrated proteomic characterization of these samples were performed, and functional enrichments based on GO and KEGG database, as well as Gene Set Enrichment Analysis were used to elucidate the pathways involved in the pathophysiology of gestational diabetes mellitus. Moreover, a weighted protein co-expression network was constructed to analysis the correlation of expression modules with clinical traits.

2025-01-21 | PXD060039 |

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