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GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms [RNA-seq]

ABSTRACT: GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms [RNA-seq]

PROVIDER: PRJNA832811 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18959200_1.fastq.gz	Fastqsanger.gz
	SRR18959200_2.fastq.gz	Fastqsanger.gz
	SRR18959201_1.fastq.gz	Fastqsanger.gz
	SRR18959201_2.fastq.gz	Fastqsanger.gz
	SRR18959202_1.fastq.gz	Fastqsanger.gz

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GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms.

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GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms [ChIP-seq]

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Project description:In order to identify GATA-3 target genes in T-cell lymphoproliferative neoplasms, we performed GATA-3 ChIP-seq on 3 cutaneous T-cell lymphoma (CTCL) and 4 T-cell acute lymphoblastic leukemia (T-ALL). We have also established cell lines in which GATA-3 was knocked down by shRNA.

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GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms.

Project description:Neoplasms originating from thymic T-cell progenitors and post-thymic mature T-cell subsets account for a minority of lymphoproliferative neoplasms. These T-cell derived neoplasms, while molecularly and genetically heterogeneous, exploit transcription factors and signaling pathways that are critically important in normal T-cell biology, including those implicated in antigen-, costimulatory-, and cytokine-receptor signaling. The transcription factor GATA-3 regulates the growth and proliferation of both immature and mature T cells and has recently been implicated in T-cell neoplasms, including the most common mature T-cell lymphoma observed in much of the Western world. Here we show that GATA-3 is a proto-oncogene across the spectrum of T-cell neoplasms, including those derived from T-cell progenitors and their mature progeny, and further define the transcriptional programs that are GATA-3 dependent, which include therapeutically targetable gene products. The discovery that p300-dependent acetylation regulates GATA-3 mediated transcription by attenuating DNA binding has novel therapeutic implications. As most patients afflicted with GATA-3 driven T-cell neoplasms will succumb to their disease within a few years of diagnosis, these findings suggest opportunities to improve outcomes for these patients.

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GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms.

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