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Vasoactive intestinal peptide expressing pDC effects on T cells

ABSTRACT: Vasoactive intestinal peptide expressing pDC effects on T cells

PROVIDER: PRJNA835081 | ENA |

REPOSITORIES: ENA

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Vasoactive intestinal peptide expressing pDC effects on T cells

Project description:B10.BR mice were lethally irradiated and infused with 5000 FACS-sorted HSCs and 1000000 T cells from C57B/6J donors with 50000 FACS-purified wild-type pDCs or VIP-KO pDCs. On day 8 and day 15 after the bone marrow transplant, donor T cells were isolated and the RNA expression were detected.

2022-05-05 | GSE201474 | GEO

Cholangiocytic cysts (CCs) treated with or without vasoactive intestinal peptide (VIP)

Project description:Cholangiocytic cysts (CCs) treated with or without vasoactive intestinal peptide (VIP)

| PRJNA580026 | ENA

Median Raphe Glutamatergic and Serotonergic Inputs Support Recruitment of Hippocampal CA1 VIP Interneurons During Novel Experience

Project description:We sequenced thirteen vasoactive intestinal peptide (VIP)-expressing interneurons from the mouse CA1 oriens/alveus area using patch-seq technique to determine their molecular identity.

2025-04-18 | GSE294910 | GEO

A novel hippocampal long-range VIP-GABAergic projection to subiculum contributes to fear memory formation through region-specific connectivity

Project description:We sequenced seven long-range projection vasoactive intestinal peptide (VIP)-expressing interneurons from the mouse CA1 oriens/alveus area using patch-seq technique to determine their molecular identity.

2018-01-30 | GSE109755 | GEO

Transcriptional effects of VIP on murine intestinal stem cells

Project description:In our study, we investigated the effect of Vasoactive intestinal peptide (VIP) on murine intestinal stem cell (ISC) activity and differentiation in homeostatic conditions and following irradiation-induced injury. We utilized a model of murine intestinal organoids and observed that VIP promotes epithelial differentiation towards a secretory phenotype predominantly via the p38 MAPK pathway. Moreover, VIP prominently modulates epithelial proliferation as well as the number and proliferative activity of Lgr5-EGFP+ ISC under homeostatic conditions. Further analysis revealed that in vitro acute irradiation injury renders Lgr5-EGFP+ ISC even more susceptible to modulations by VIP, which results in the strong promotion of epithelial regeneration by VIP. Finally, these effects by VIP translate into an in vivo model of abdominal irradiation, where VIP was shown to prominently mitigate radiation-induced injury. Taken together, our findings indicate a prominent role of VIP in modulating ISC behavior in intestinal homeostasis and its potential to promote intestinal regeneration following acute irradiation injury.

2024-09-27 | GSE261001 | GEO

Formyl peptide receptor 2 contributes to intestinal epithelium homeostasis by regulating intestinal stem cell proliferation and differentiation

Project description:In this study, we investigated the involvement of formyl peptide receptor 2 (FPR2) in intestinal epithelium homeostasis and the underlying mechanisms by comparing the transcriptome profiles of intestinal crypts from intestinal epithelial-specific knockout (Fpr2VKO) and control (Fpr2f/f) mice.

2025-03-24 | GSE292366 | GEO

RNA sequencing of HEK293T cells expressing peptide 9J10, a 14-3-3 interacting peptide

Project description:RNA sequencing of HEK293T cells expressing peptide 9J10, a 14-3-3 interacting peptide

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The contribution of formyl peptide receptor 2 to intestinal epithelium homeostasis

Project description:To elucidate the mechanisms involved in maintaining intestinal epithelial homeostasis through formyl peptide receptor 1 (FPR2), small intestinal organoids derived from Fpr2f/f mice were used as an ex vivo model. Transcriptomics were examined via RNA-seq following FPR2 activation with MMK-1.

2025-11-23 | GSE310387 | GEO

Mice with targeted deletion of the Vasoactive Intestinal Peptide (VIP) gene have spontaneous pulmonary arterial hypertension exaggerated with hypoxia

Project description:We earlier reported spontaneous moderate pulmonary arterial hypertension in Vasoactive Intestinal Peptide (VIP) gene knockout mice. In the current study, we show accelerated pulmonary artery pressure changes associated with vascular and cardiac remodeling changes in VIP KO mice subjected to hypoxia compared to control wild-type C57BL/6 mice in hypoxia chambers. There is differential whole-lung RNA sequencing expression between baseline normoxia wild-type and VIP KO mice groups. Under conditions of hypoxia vs. normoxia, we observe upregulation of spatial biology expression of CD45 in VIP KO mice with hypoxia, but not in wild-type mice with hypoxia. Moreover, wild-type hypoxia mice express alpha-actin and CD31, which is not seen in the VIP KO hypoxia cohort. Human lung tissue from pediatric patients with idiopathic pulmonary arterial hypertension (PAH) lacks immunohistochemical evidence of VIP, supporting the concepts that VIP plays a critical role in the immunopathogenesis of pulmonary hypertension and VIP or its analogues may potentially be used to treat PAH.

2026-01-03 | GSE315475 | GEO

Formyl peptide receptor 2 contributes to intestinal epithelium homeostasis by regulating intestinal stem cell proliferation and differentiation [scRNA-seq]

Project description:To investigate the contribution of formyl peptide receptor 2 (FPR2) to intestinal epithelium homeostasis and the underlying mechanisms, we isolated small intestinal crypts from intestinal epithelial-specific knockout (Fpr2VKO) and control (Fpr2f/f) mice, isolated epithelial cells from the crypts and performed single-cell RNA sequencing (scRNA-Seq). The transcriptome profiles of Fpr2VKO and Fpr2f/f mice were compared.

2025-03-31 | GSE292802 | GEO

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