Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (RNA-Seq II)

ABSTRACT: Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (RNA-Seq II)

PROVIDER: PRJNA835118 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR19086884.fastq.gz	Fastqsanger.gz
	SRR19086885.fastq.gz	Fastqsanger.gz
	SRR19086886.fastq.gz	Fastqsanger.gz
	SRR19086887.fastq.gz	Fastqsanger.gz
	SRR19086888.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis

Project description:Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis

| PRJNA835114 | ENA

Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (ATAC-Seq)

Project description:Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (ATAC-Seq)

| PRJNA835117 | ENA

Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (ChIP-Seq)

Project description:Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (ChIP-Seq)

| PRJNA835120 | ENA

Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (RNA-Seq III)

Project description:Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (RNA-Seq III)

| PRJNA919008 | ENA

Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (RNA-Seq I)

Project description:Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (RNA-Seq I)

| PRJNA835119 | ENA

Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (ATAC-Seq)

Project description:Mitotic entry correlates with remodeling of histone modifications, chromatin condensation, exclusion of transcription factors from the DNA and broad downregulation of transcription. However, whether mitotic condensation also influences interphase transcription is a question that has not been addressed yet. In this study, we reveal that loss of mitotic chromatin condensation results in a dramatic and spontaneous recruitment of the transcription machinery and unscheduled initiation of gene expression. This includes activation of inducible transcriptional programs, which occurs even in absence of relevant stimuli, such as the GAL system. Strikingly, such an erratic gene expression goes on after exit from mitosis. Thus, we reveal a novel function of mitotic chromosome condensation, i.e. resetting the transcriptome to prevent gene expression from drifting and maintain transcriptional homeostasis during interphase.

2025-05-03 | GSE202246 | GEO

Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (ChIP-Seq)

2025-05-03 | GSE202247 | GEO