Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Effects of diabetes mellitus with stroke on the intestinal flora

PROVIDER: PRJNA835861 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR19128908_1.fastq.gz	Fastqsanger.gz
	SRR19128908_2.fastq.gz	Fastqsanger.gz
	SRR19128909_1.fastq.gz	Fastqsanger.gz
	SRR19128909_2.fastq.gz	Fastqsanger.gz
	SRR19128910_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 40

Similar Datasets

Effect of gestational diabetes mellitus on intestinal flora and its effect on congenital kidney malformation through gpr43 pathway

Project description:Bioinformatics analysis combined with in vitro and in vivo experiments revealed the characteristics of intestinal flora and metabolic differences in patients with gestational diabetes mellitus (GDM), and the mechanism of affecting gpr43 pathway and thus affecting the offspring's congenital anomalies of the kidney and the urinary tract (CAKUT)

2025-06-03 | PXD064555 |

Project description:Correlation between FOXC2 gene C-512T polymorphism and intestinal flora in diabetes mellitus

| PRJNA950549 | ENA

Polysaccharides from Sargassum fusiforme protect mice against Citrobacter rodentium infection through intestinal microbiota-drived microRNA-92a-3p

Project description:To explore the regulatory mechanism of intestinal flora in Citrobacter rodentium -induced intestinal infection by transcriptome analysis at miRNA molecular level.

2024-03-04 | GSE260446 | GEO

Project description:Potential impact of oral and intestinal flora and oral-intestinal flora intertransmission on stroke patients

| PRJNA1185666 | ENA

gut metagenome

Project description:Study of intestinal microorganisms in gestational diabetes mellitus patients.

| PRJNA556764 | ENA

Project description:Effect of gestational diabetes mellitus on intestinal flora and its effect on congenital kidney malformation through gpr43 pathway

| PRJNA1271241 | ENA

human gut metagenome

Project description:Effects of drugs on intestinal flora

| PRJNA1057786 | ENA

Serum microRNA profile of human type 1 diabetes mellitus

Project description:To evaluate whether serum micoRNAs can be biomarkers for diagnosis of type 1 diabetes mellitus, we analyzed the serum microRNA expression profiles in 6 patients with new-onset type 1 diabetes mellitus and 6 age- and gender-matched healthy controls. A difference was observed in 31 miRNAs between the patients and controls (fold change ≥ 2, P < 0.05)

2017-02-09 | GSE94649 | GEO

Project description:Regulation of intestinal flora by Suaeda salsa extract ameliorates hyperglycemia in a mouse model of type 2 diabetes mellitus

| PRJNA1187325 | ENA

Effects of human adipose tissue-derived and umbilical cord tissue-derived mesenchymal stem cells in a dextran sulfate sodium-induced mouse model

Project description:Background: Mesenchymal stem cells (MSCs) can be acquired from medical waste. MSCs are easily expanded and have multiple functions, including anti-inflammatory effects. We evaluated the effects of human adipose tissue-derived MSCs (AD-MSCs) and umbilical cord tissue-derived MSCs (UC-MSC) in a dextran sulfate sodium (DSS)-induced mouse model. Methods: Human AD-MSCs and UC-MSCs (1 × 106 cells) were injected intravenously into a 7-day DSS-induced colitis model. The therapeutic effects of cell origin, injection timing, and supernatants obtained from MSC cultures were evaluated. We also analyzed mRNA expression in MSCs, tissues, and intestinal flora. Results: AD-MSCs and UC-MSCs had strong anti-inflammatory effects when injected on day 3 in a mouse model. On day 11, mRNA levels of inflammatory factors in colon tissues were significantly decreased after injection of MSCs on day 3. Supernatants from MSCs culture decreased mRNA levels of tumor necrosis factor (Tnf)-α, but had reduced therapeutic effects compared with MSC cell injection. RNA sequencing using colon tissues obtained the day after cell injection revealed changes in the TNF-α/nuclear factor-κB and T-cell receptor signaling pathways. Additional analyses showed that several factors, including chromosome 10 open reading frame 54, stanniocalcin-1, and TNF receptor superfamily member 11b were increased in MSCs after adding serum from DSS colitis mice. Furthermore, both AD-MSCs and UC-MSCs maintained the balance of intestinal flora. Conclusion: AD-MSCs and UC-MSCs showed therapeutic effects against inflammation after early cell injection while maintaining the intestinal flora. Although supernatants showed therapeutic effects, cell injection was more effective against inflammation.

2019-11-19 | GSE136397 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data