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ABSTRACT: The gut microbiota in IgAN patients and healthy controls .

PROVIDER: PRJNA837902 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19198000_1.fastq.gz	Fastqsanger.gz
	SRR19198000_2.fastq.gz	Fastqsanger.gz
	SRR19198001_1.fastq.gz	Fastqsanger.gz
	SRR19198001_2.fastq.gz	Fastqsanger.gz
	SRR19198002_1.fastq.gz	Fastqsanger.gz

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Project description:Gut microbiome analysis between IgAN patients and healthy controls

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MicroRNA profiling by array of human urinary sediments from IgAN patients

Project description:We have performed a microRNA expression analysis in urine sediments from 18 IgAN patients, 6 healthy subjects and 8 disease controls(including 4 membranous nephropathy patients and 4 minimal change disease patients). Pathologic diagnosis of all IgAN patients was included in grades I–V by light microscopy according to the grading system of Lee et al. And we have identified a set of deregulated microRNAs with potential diagnostic value to identify patients with IgAN.

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Project description:Rationale: Recent studies suggest a potential link between gut bacterial microbiota dysbiosis and PAH, but the exact role of gut microbial communities, including bacteria, archaea, and fungi, in PAH remains unclear. Objectives: To investigate the role of gut microbiota dysbiosis in idiopathic pulmonary arterial hypertension (IPAH) and to assess the therapeutic potential of fecal microbiota transplantation (FMT) in modulating PAH progression. Methods: Using shotgun metagenomics, we analyzed gut microbial communities in IPAH patients and healthy controls. FMT was performed to transfer gut microbiota from IPAH patients or MCT-PAH rats to normal rats and from healthy rats to MCT-PAH rats. Hemodynamic measurements, echocardiography, histological examination, metabolomic and RNA-seq analysis were conducted to evaluate the effects of FMT on PAH phenotypes. Measurements and Main Results: Gut microbiota analysis revealed significant alterations in the bacterial, archaeal, and fungal communities in IPAH patients compared to healthy controls. FMT from IPAH patients induced PAH phenotypes in recipient rats. Conversely, FMT from healthy rats to IPAH rats significantly ameliorated PAH symptoms, restored gut microbiota composition, and normalized serum metabolite profiles. Specific microbial species were identified with high diagnostic potential for IPAH, improving predictive performance beyond individual or combined microbial communities. Conclusions: This study establishes a causal link between gut microbiota dysbiosis and IPAH and demonstrates the therapeutic potential of FMT in reversing PAH phenotypes. The findings highlight the critical role of bacterial, archaeal, and fungal communities in PAH pathogenesis and suggest that modulation of the gut microbiome could be a promising treatment strategy for PAH.

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Altered modulation of WNT-Î²-catenin and PI3K/Akt pathways in IgA nephropathy

Project description:To uncover new molecular mechanisms involved in IgAN pathogenesis, we compared the genomic profiles of 12 IgAN patients with 8 healthy subjects, We included addiotional disease controls 3 FSGS(Focal Segmenal glomerulosclerosis) patients and 3 membrano proliferative glomerulonephritis type I (MPGN-I) controls in our study to evaluate if the WNT-Î²-catenin and PI3K/Akt pathways were specfic to IgAN. Gene expression profile comparison between 12IgAN patients and 8 Healthy Subjects. Gene Set Enrichment Analysis (GSEA) performed on the additional disease controls determined that the a priori defined set of genes and the pathways generated were specific to the IgAN

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