Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Gigante Feedback experiment

PROVIDER: PRJNA838257 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR19214900_1.fastq.gz	Fastqsanger.gz
	SRR19214900_2.fastq.gz	Fastqsanger.gz
	SRR19215000_1.fastq.gz	Fastqsanger.gz
	SRR19215000_2.fastq.gz	Fastqsanger.gz
	SRR19215100_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 1046

Similar Datasets

Project description:Arabidopsis thaliana feedback experiment

| PRJNA1044307 | ENA

uncultured bacterium

Project description:Litter Addition and Feedback Experiment

| PRJNA529920 | ENA

Project description:Feedback-to-Innate ratio manipulation experiment

| PRJNA941033 | ENA

Project description:Soil microbes associated with Phragmites australis in a controlled plant-soil feedback experiment

| PRJNA719385 | ENA

Project description:Feedback

| PRJNA1135684 | ENA

Project description:Feedback

| PRJNA1135494 | ENA

Project description:Rhizosphere feedback project

| PRJNA1026929 | ENA

Transcriptional Repressor Gm129 Modulates the Circadian Gene Expression by Inhibiting CLOCK:BMAL1 Activity

Project description:The mammalian circadian clock is a molecular oscillator composed of a feedback loop that involves transcriptional activators CLOCK and BMAL1, and repressors Cryptochrome (CRY) and Period (PER). Here we show that a direct CLOCK-BMAL1 target gene, Gm129, is a novel regulator of the feedback loop. ChIP analysis revealed that the CLOCK:BMAL1:CRY1 complex strongly occupies the promoter region of Gm129. Both mRNA and protein levels of GM129 exhibit high amplitude circadian oscillations in mouse liver, and Gm129 gene encodes a nuclear-localized protein that directly interacts with BMAL1 and represses CLOCK:BMAL1 activity. In vitro and in vivo protein-DNA interaction results demonstrate that, like CRY1, GM129 functions as a repressor by binding to the CLOCK:BMAL1 complex on DNA. Although Gm129-/- or Cry1-/- Gm129-/- mice retain a robust circadian rhythm, the peaks of Nr1d1 and Dbp mRNAs in liver exhibit significant phase delay compared to control. Our results suggest that, in addition to CRYs and PERs, GM129 protein contributes to the transcriptional feedback loop by modulating CLOCK:BMAL1 activity as a transcriptional repressor. Examination of 3 transcriptional regulators in mouse liver

2014-01-07 | E-GEOD-53828 | biostudies-arrayexpress

Project description:Plant-soil feedback-Bacteria

| PRJNA1217353 | ENA

Project description:Plant-soil feedback-fungi

| PRJNA1217354 | ENA