Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Temporally-Divergent Regulatory Mechanisms Govern Neuronal Diversification and Maturation in the Neocortex

ABSTRACT: Temporally-Divergent Regulatory Mechanisms Govern Neuronal Diversification and Maturation in the Neocortex

PROVIDER: PRJNA842558 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR19391431.fastq.gz	Fastqsanger.gz
	SRR19391431_1.fastq.gz	Fastqsanger.gz
	SRR19391431_2.fastq.gz	Fastqsanger.gz
	SRR19391831_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 177

Similar Datasets

Temporally-Divergent Regulatory Mechanisms Govern Neuronal Diversification and Maturation in the Neocortex [WGBS]

Project description:Temporally-Divergent Regulatory Mechanisms Govern Neuronal Diversification and Maturation in the Neocortex [WGBS]

| PRJNA842146 | ENA

Temporally-Divergent Regulatory Mechanisms Govern Neuronal Diversification and Maturation in the Neocortex [scRNA-seq]

Project description:Temporally-Divergent Regulatory Mechanisms Govern Neuronal Diversification and Maturation in the Neocortex [scRNA-seq]

| PRJNA842145 | ENA

Temporally-Divergent Regulatory Mechanisms Govern Neuronal Diversification and Maturation in the Neocortex [snRNA-seq]

Project description:Temporally-Divergent Regulatory Mechanisms Govern Neuronal Diversification and Maturation in the Neocortex [snRNA-seq]

| PRJNA842150 | ENA

Temporally-Divergent Regulatory Mechanisms Govern Neuronal Diversification and Maturation in the Neocortex [ATAC-seq]

Project description:Temporally-Divergent Regulatory Mechanisms Govern Neuronal Diversification and Maturation in the Neocortex [ATAC-seq]

| PRJNA842562 | ENA

Temporally-Divergent Regulatory Mechanisms Govern Neuronal Diversification and Maturation in the Neocortex [scATAC-seq]

Project description:Temporally-Divergent Regulatory Mechanisms Govern Neuronal Diversification and Maturation in the Neocortex [scATAC-seq]

| PRJNA842149 | ENA

Temporally-Divergent Regulatory Mechanisms Govern Neuronal Diversification and Maturation in the Neocortex [RNA-seq]

Project description:Temporally-Divergent Regulatory Mechanisms Govern Neuronal Diversification and Maturation in the Neocortex [RNA-seq]

| PRJNA842147 | ENA

Temporally-Divergent Regulatory Mechanisms Govern Neuronal Diversification and Maturation in the Neocortex [WGBS]

Project description:Mammalian neocortical neurons span one of the most diverse cell type spectra of any tissue. The regulatory strategies that neurons use during progressive development and maturation remain unclear. We present an integrated single-cell epigenomic and transcriptional analysis of individual classes of neurons from both mouse and marmoset neocortex, sampled during both early postmitotic stages of identity acquisition and later stages of neuronal plasticity and circuit integration. We find that in both species, the regulatory strategies controlling early and late stages of pan-neuronal development diverge. Early postmitotic neurons use molecular regulatory programs with broader tissue distribution and greater evolutionary conservation. In contrast, programs that are active during later neuronal maturation implement more brain- and neuron-specific mechanisms showing greater evolutionary divergence. Our work uncovers a temporally-regulated shift in regulatory choices, likely reflecting unique evolutionary constraints on distinct events of neuronal development in the neocortex.

2022-05-31 | GSE204758 | GEO